Molecular Imaging and Biology

, Volume 13, Issue 3, pp 411–415

Chronic Cannabinoid Administration to Periadolescent Rats Modulates the Metabolic Response to Acute Cocaine in the Adult Brain

  • Alejandro Higuera-Matas
  • Maria Luisa Soto-Montenegro
  • Gonzalo L. Montoya
  • Verónica García-Vázquez
  • Javier Pascau
  • Miguel Miguéns
  • Nuria Del Olmo
  • Juan José Vaquero
  • Carmen García-Lecumberri
  • Manuel Desco
  • Emilio Ambrosio
Brief Article

DOI: 10.1007/s11307-010-0388-8

Cite this article as:
Higuera-Matas, A., Soto-Montenegro, M.L., Montoya, G.L. et al. Mol Imaging Biol (2011) 13: 411. doi:10.1007/s11307-010-0388-8

Abstract

Purpose

To analyze brain metabolic response to acute cocaine in male and female Wistar rats with or without a history of cannabinoid exposure during periadolescence.

Procedures

The synthetic cannabinoid agonist CP 55,940 (CP) or its vehicle (VH), were administered to male and female rats during periadolescence. When these animals reached adulthood, saline and cocaine-induced changes in 2-deoxy-2-[18F]fluoro-D-glucose (FDG) uptake were studied by positron emission tomography.

Results

The baseline (post-saline) metabolism in the septal nuclei was higher in CP-females than in VH-females, although septal metabolism was lower in CP-females after cocaine, reaching similar values to those of VH-females at baseline. Cocaine did not affect metabolism in VH-females. Periadolescent cannabinoid treatment did not influence baseline metabolism in males although cocaine reduced the FDG uptake in the dorsal striatum of males that received the VH but not CP.

Conclusions

These results suggest that cannabinoids during periadolescence modify baseline and cocaine-evoked brain metabolism in a sex-dependent manner. In the case of CP-females, the involvement of septal metabolic alterations in their susceptibility to the rewarding effects of cocaine should be further investigated.

Key words

Cannabinoids Cocaine Dorsal striatum PET Septal nuclei 

Copyright information

© Academy of Molecular Imaging and Society for Molecular Imaging 2010

Authors and Affiliations

  • Alejandro Higuera-Matas
    • 1
    • 5
  • Maria Luisa Soto-Montenegro
    • 2
    • 3
  • Gonzalo L. Montoya
    • 1
    • 2
  • Verónica García-Vázquez
    • 3
  • Javier Pascau
    • 2
  • Miguel Miguéns
    • 1
  • Nuria Del Olmo
    • 4
  • Juan José Vaquero
    • 2
  • Carmen García-Lecumberri
    • 1
  • Manuel Desco
    • 2
    • 3
  • Emilio Ambrosio
    • 1
  1. 1.Psychobiology DepartmentSchool of Psychology, UNEDMadridSpain
  2. 2.Unidad de Medicina y Cirugía Experimental, Hospital General Universitario Gregorio MarañónMadridSpain
  3. 3.CIBERSAMMadridSpain
  4. 4.Department of Pharmaceutical and Food Sciences, School of PharmacyCEU UniversityMadridSpain
  5. 5.Department of Pharmacology, School of MedicineUniversidad ComplutenseMadridSpain

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