The clinical utility of positron emission tomography/computed tomography (PET/CT) in comparison to standard workup in patients with known or suspected inflammatory bowel disease (IBD) is unknown.
Clinical data were collected on seven patients with known or suspected IBD undergoing PET/CT. Standard workup included history, physical exam, laboratory tests, colonoscopy and/or cross-sectional imaging. We divided the intestine into five regions [small bowel and four colon (ascending, transverse, descending and rectosigmoid)] and graded relative standard uptake values 0, 1, 2 or 3 by comparison to the liver, using a region-of-interest analysis (0 = no activity, 1 = liver, 2 and 3 = significant inflammation).
In patients 1 and 2, PET/CT demonstrated more activity than we thought clinically present. The other patients avoided unnecessary escalation or initiation of IBD therapy based on PET/CT results. Compared with standard workup, all seven patients had superior results when therapeutic decisions were based on PET/CT.
We found PET/CT to be very useful in diagnosis and management in patients with known or suspected IBD.
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This study was funded in part by an unrestricted grant from Proctor & Gamble Pharmaceuticals.
None of the authors have conflicts to disclose.
This is an article describing the clinical utility of PET/CT compared to standard workup in patients with known or suspected IBD. This manuscript is important as it evaluates the use of PET/CT to guide clinical management in patients with known or suspected IBD.
Financial Disclosures: This study was funded in part by an unrestricted grant from Proctor & Gamble Pharmaceuticals.
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Lapp, R.T., Spier, B.J., Perlman, S.B. et al. Clinical Utility of Positron Emission Tomography/Computed Tomography in Inflammatory Bowel Disease. Mol Imaging Biol 13, 573–576 (2011). https://doi.org/10.1007/s11307-010-0367-0
- Inflammatory Bowel Disease
- Crohn's colitis
- Ulcerative Colitis