Molecular Imaging and Biology

, Volume 12, Issue 4, pp 452–459 | Cite as

Performance of Integrated FDG-PET/Contrast-enhanced CT in the Diagnosis of Recurrent Pancreatic Cancer: Comparison with Integrated FDG-PET/Non-contrast-enhanced CT and Enhanced CT

  • Kazuhiro Kitajima
  • Koji Murakami
  • Erena Yamasaki
  • Yasushi Kaji
  • Mitsugi Shimoda
  • Keiichi Kubota
  • Narufumi Suganuma
  • Kazuro Sugimura
Research Article



The purpose of this study is to evaluate the accuracy of 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography (FDG-PET)/computed tomography (CT) with intravenous contrast for depiction of recurrent pancreatic cancer, compared with PET/non-enhanced CT and CT.


Forty-five patients previously treated for pancreatic cancer underwent PET/CT for suspected recurrence. Lesion status was determined on the basis of histopathology and radiological imaging follow-up.


Patient-based analysis showed that sensitivity, specificity, and accuracy of PET/contrast-enhanced CT were 91.7%, 95.2%, and 93.3%, respectively, whereas those of PET/non-enhanced CT were 83.3%, 90.5%, and 86.7%, respectively, and those of enhanced CT were 66.7%, 85.7%, and 75.6%, respectively. In 21 patients whom the final diagnosis was obtained from the histopathologic examination, those figures of PET/contrast-enhanced CT were 94.7%, 50.0%, and 90.4%, respectively. The sensitivity of PET/contrast-enhanced CT in detecting local recurrence, abdominal lymph node metastasis, and peritoneal dissemination were 83.3%, 87.5%, and 83.3%, respectively.


PET/contrast-enhanced CT is an accurate modality for assessing recurrence of pancreatic cancer.

Key words

Pancreatic cancer Recurrence 18F-FDG PET/CT 



We thank Kennichi Kobayashi, Kouichi Asano, Kazufumi Suzuki, Kaoru Ishida, and Tomoyuki Sakamoto for their excellent technical assistance and generous support.


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Copyright information

© Academy of Molecular Imaging 2009

Authors and Affiliations

  • Kazuhiro Kitajima
    • 1
    • 2
    • 5
  • Koji Murakami
    • 2
  • Erena Yamasaki
    • 2
  • Yasushi Kaji
    • 1
  • Mitsugi Shimoda
    • 3
  • Keiichi Kubota
    • 3
  • Narufumi Suganuma
    • 4
  • Kazuro Sugimura
    • 5
  1. 1.Department of RadiologyDokkyo University School of MedicineMibuJapan
  2. 2.PET CenterDokkyo Medical University HospitalMibuJapan
  3. 3.Second Department of SurgeryDokkyo University School of MedicineMibuJapan
  4. 4.Department of Environmental MedicineKochi University Medical SchoolKochiJapan
  5. 5.Department of RadiologyKobe University Graduate School of MedicineKobeJapan

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