Molecular Imaging and Biology

, 11:343 | Cite as

NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of 3′-Deoxy-3′-[18F]fluorothymidine (FLT) as a Marker of Proliferation in Patients with Recurrent Gliomas: Preliminary Efficacy Studies

  • Alexander M. Spence
  • Mark Muzi
  • Jeanne M. Link
  • Finbarr O’Sullivan
  • Janet F. Eary
  • John M. Hoffman
  • Lalitha K. Shankar
  • Kenneth A. Krohn
Research Article

Abstract

Purpose

3′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT) is being developed for imaging cellular proliferation. The goals were to explore the capacity of FLT-positron emission tomography (PET) to distinguish between recurrence and radionecrosis in gliomas and compare the results to those obtained with 2-fluoro-2-deoxy-d-glucose (FDG).

Procedures

Fifteen patients with tumor recurrence and four with radionecrosis, determined by clinical course and magnetic resonance imaging results, were studied by dynamic [18F]FLT-PET with arterial blood sampling. A two-tissue compartment four-rate constant model was used to determine metabolic flux (K FLT), blood to tissue transport (K 1), and phosphorylation (k 3). FDG-PET scans were obtained 75–90 min postinjection.

Results

K FLT and k 3, but not K 1 or k 3/k 2 + k 3, reached significance for separating the recurrence from radionecrosis groups. Standardized uptake value and visual analyses of FLT or FDG images did not reach significance.

Conclusions

K FLT (flux) appears to distinguish recurrence from radionecrosis better than other parameters, FLT and FDG semiquantitative approaches, or visual analysis of images of either tracer.

Key Words

3′-[18F]fluoro-3′-deoxythymidine FLT Fluorothymidine Positron emission tomography (PET) Glioma Radionecrosis Proliferation imaging 

Notes

Acknowledgments

Pam Pham, Michele F. Wanner, Jeffrey Scharnhorst, and Neha Patel are gratefully acknowledged for their indispensable help. Supported by National Cancer Institute Contract N01-CM-37008 and NIH grants CA42045 and S10 RR17229.

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Copyright information

© Academy of Molecular Imaging 2009

Authors and Affiliations

  • Alexander M. Spence
    • 1
  • Mark Muzi
    • 2
  • Jeanne M. Link
    • 2
  • Finbarr O’Sullivan
    • 3
  • Janet F. Eary
    • 2
  • John M. Hoffman
    • 4
  • Lalitha K. Shankar
    • 5
  • Kenneth A. Krohn
    • 2
  1. 1.Department of NeurologyUniversity of WashingtonSeattleUSA
  2. 2.Department of RadiologyUniversity of WashingtonSeattleUSA
  3. 3.Department of StatisticsUniversity College CorkCorkIreland
  4. 4.Departments of Radiology and NeurologyUniversity of UtahSalt Lake CityUSA
  5. 5.Cancer Imaging Program, Division of Cancer Treatment and DiagnosisNational Cancer InstituteBethesdaUSA

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