Molecular Imaging and Biology

, Volume 10, Issue 5, pp 271–280 | Cite as

NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of FLT as a Marker of Proliferation in Patients with Recurrent Gliomas: Safety Studies

  • Alexander M. Spence
  • Mark Muzi
  • Jeanne M. Link
  • John M. Hoffman
  • Janet F. Eary
  • Kenneth A. Krohn
Research Article

Abstract

Purpose

3’-[F-18]Fluoro-3’-deoxythymidine (FLT) is an analog of thymidine that is being developed for imaging cellular proliferation. The goal of this study was to prove that the dose of FLT used for positron emission tomography imaging produces no significant toxicity.

Procedures

Twelve patients with gliomas with either recurrence or suspected radionecrosis were imaged with FLT. Before and at several time points after imaging, subjects underwent general physical and neurological examinations with review of systems and tests of hematologic, hepatic, renal, and several other metabolic parameters. Vital signs and electrocardiograms were monitored during and after the imaging session.

Results

There were no significant adverse effects from FLT injected at a dose of 0.07 mCi/kg (maximum of 5 mCi) at specific activities of 1.25 Ci/μmol or higher. The FLT mass administered for imaging was 0.0001% to 0.0009% of the least toxic cumulative dose administered in clinical trials of FLT as an antiretroviral agent.

Conclusions

FLT is a safe radiotracer for quantifying proliferation in the human cancer setting.

Key words

3’-[F-18]fluoro-3’-deoxythymidine FLT Fluorothymidine Positron emission tomography (PET) Glioma Glioblastoma Safety Toxicity Proliferation 

Notes

Acknowledgments

Lalitha K. Shankar, M.D., Ph.D., and Paula M. Jacobs, Ph.D. are gratefully acknowledged for their indispensable help with the contracts and the statistical analyses. This study was supported by National Cancer Institute Contract N01-CM-37008, Subcontract NCI (CIP/SAIC) BOA 24XS036 and S10 RR17229.

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Copyright information

© Academy of Molecular Imaging 2008

Authors and Affiliations

  • Alexander M. Spence
    • 1
  • Mark Muzi
    • 2
  • Jeanne M. Link
    • 2
  • John M. Hoffman
    • 3
  • Janet F. Eary
    • 2
  • Kenneth A. Krohn
    • 2
  1. 1.Department of NeurologyUniversity of WashingtonSeattleUSA
  2. 2.Department of RadiologyUniversity of WashingtonSeattleUSA
  3. 3.Departments of Radiology and NeurologyUniversity of UtahSalt Lake CityUSA

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