Molecular Imaging and Biology

, Volume 10, Issue 3, pp 162–166 | Cite as

Reproducibility of Semi-quantitative Parameters in FDG-PET Using Two Different PET Scanners: Influence of Attenuation Correction Method and Examination Interval

  • Tomohito Kamibayashi
  • Tatsuro TsuchidaEmail author
  • Yoshiki Demura
  • Tetsuya Tsujikawa
  • Hidehiko Okazawa
  • Takashi Kudoh
  • Hirohiko Kimura
Research Article



The aim of this study is to evaluate the reproducibility of semi-quantitative parameters obtained from two 2-deoxy-2-[F-18]fluoro-d-glucose-positron emission tomography (FDG–PET) studies using two different PET scanners.


Forty-five patients underwent FDG–PET examination with two different PET scanners on separate days. Two PET images with different attenuation correction method were generated in each patient, and three regions of interest (ROIs) were placed on the lung tumor and normal organs (mediastinum and liver) in each image. Mean and maximum standardized uptake values (SUVs), tumor-to-mediastinum and tumor-to-liver ratios (T/M and T/L), and the percentage difference in parameters between two PET images (% Diff.) were compared.


All measured values except maximum SUV in the liver and tumor-related parameters (SUV in lung tumor, T/M, T/L) showed no significant difference between two PET images.


The mean measured values showed high reproducibility and demonstrate that follow-up study or measurement of tumor response to anticancer drugs can be undertaken by FDG–PET examination without specifying the particular type of PET scanner.

Key words

PET PET/CT Reproducibility Standardized uptake value Lung tumor 


  1. 1.
    Delbeke D (1999) Oncological applications of FDG PET imaging. J Nucl Med 40:1706–1715PubMedGoogle Scholar
  2. 2.
    Wahl R, Quint L, Cieslak R, Aisen A, Koeppe R, Meyer C (1993) “Anatometabolic” tumor imaging: fusion of FDG PET with CT or MRI to localize Foci of increased activity. J Nucl Med 34:1190–1197PubMedGoogle Scholar
  3. 3.
    Turkington T, Jaszczak R, Pelizzari C, Pelizzari C, Harris C, MacFall J et al. (1993) Accuracy of registration of PET, SPECT and MR images of a brain phantom. J Nucl Med 34:1587–1594PubMedGoogle Scholar
  4. 4.
    West J, Fitzpatrick JM, Wang MY, Dawant BM, Maurer CR Jr., Kessler RM et al. (1997) Comparison and evaluation of retrospective intermodality brain image registration techmiques. J Comput Assist Tomogr 21:554–566PubMedCrossRefGoogle Scholar
  5. 5.
    Uematsu H, Sadato N, Yonekura Y, Tsuchida T, Nakamura S, Sugimoto K et al. (1998) Coregistration of FDG PET and MRI of the head and neck using normal distribution of FDG. J Nucl Med 39:2121–2127PubMedGoogle Scholar
  6. 6.
    Beyer T, Townsend D, Brun T, Kinahan P, Charron M, Roddy R et al.. (2000) A combined PET/CT scanner for clinical oncology. J Nucl Med 41:784–788Google Scholar
  7. 7.
    Kluetz P, Meltzer C, Villemagne V, Kinahana P, Chander S, Martinelli M et al (2000) Combined PET/CT imaging in oncology impact on patient management. Clin Positron Imaging 3:223–230PubMedCrossRefGoogle Scholar
  8. 8.
    Keyes J Jr. (1995) SUV: standard uptake or silly unless value? J Nucl Med 36:1836–1839PubMedGoogle Scholar
  9. 9.
    Huang S-C (2000) Anatomy of SUV. Nucl Med Biol 27:643–646PubMedCrossRefGoogle Scholar
  10. 10.
    Lee JR, Madsen MT, Bushnel D, Menda Y (2000) A threshold method to improve standardized uptake value reproducibility. Nucl Med Commun 21:685–690PubMedCrossRefGoogle Scholar
  11. 11.
    Young H, Baum R, Cremerius U, Herholz K, Hoekstra O, Lammertsma A et al. (1999) Mesurement of clinical and subclinical tumour response using [18F]-fluorodeoxyglucose and positron emission tomography: review and 1999 EORTC recommendations. Eur J Cancer 35:1773–1782PubMedCrossRefGoogle Scholar
  12. 12.
    Ramos C, Erdi Y, Gonen M, Riedel E, Yeung H, Macapinlac H et al. (2001) FDG–PET standardized uptake values in normal anatomical structures using iterative reconstruction segmented attenuation correction and filtered back-projection. Eur J Nucl Med 28:155–164PubMedCrossRefGoogle Scholar
  13. 13.
    Nakamoto Y, Osman M, Cohade C, Marshall L, Links J, Kohlmyer S et al. (2002) PET/CT: Comparison of quantitative tracer uptake between germanium and CT transmission attenuation-corrected images. J Nucl Med 43:1137–1143PubMedGoogle Scholar
  14. 14.
    Kamel E, Hany T, Burger C, Treyer V, Lonn A, von Schulthess G et al. (2002) CT vs 68Ge attenuation correction in a combined PET/CT system: evaluation of the effect of lowering the CT tube current. Eur J Nucl Med Mol Imaging 29:346–350PubMedCrossRefGoogle Scholar
  15. 15.
    Souvatzoglou M, Ziegler S, Martinez M, Busch R, Dzewas G, Schwaiger M et al. (2007) Standardised uptake values from PET/CT images: comparison with conventional attenuation-corrected PET. Eur J Nucl Med Mol Imaging 34:405–412PubMedCrossRefGoogle Scholar
  16. 16.
    Weber W, Ziegler S, Thödtmann R, Hanauske A, Schwaiger M (1999) Reproducibility of metabolic measurements in malignant tumors using FDG PET. J Nucl Med 40:1771–1777PubMedGoogle Scholar
  17. 17.
    Minn H, Zasadny K, Quint L, Wahl R (1995) Lung cancer: Reproducibility of quantitative measurements for evaluating 2-[F-18]-fluoro-2-deoxy-d-glucose uptake at PET. Radiology 196:167–173PubMedGoogle Scholar
  18. 18.
    Nakamoto Y, Zasadny K, Minn H, Wahl R (2002) Reproducibility of common semi-quantitative parameters for evaluating lung cancer glucose metabolism with positron emission tomography using 2-deoxy-2-[18F]fluoro-d-glucose. Mol Imaging Biol 4:171–178PubMedCrossRefGoogle Scholar
  19. 19.
    Paquet N, Albert A, Foidart J, Hustinx R (2004) Within-patient variability of 18F-FDG: standardized uptake values in normal tissue. J Nucl Med 45:784–788PubMedGoogle Scholar
  20. 20.
    Snedocor GW, Cochran WG (1989) Specific indices of interater reliability. In: Snedocor GW, Cochran WG (eds) Statistical methods. 6th edn. Iowa State University Press, Ames, IO, pp 147–156Google Scholar
  21. 21.
    Shrout PE, Fleiss JL (1979) Intraclass correlations: uses in assessing rater reliability. Psychol Bull 86:420–428CrossRefGoogle Scholar
  22. 22.
    Hamberg L, Hunter G, Alpert N, Choi N, Babich J, Fischman A (1994) The dose uptake ratio as index of glucose metabolism: useful parameter or oversimplification? J Nucl Med 35:1308–1312PubMedGoogle Scholar
  23. 23.
    Visvikis D, Cheze-LeRest C, Costa DC, Bomanji J, Gacinovic S, Ell PJ (2001) Influence of OSEM and segmented attenuation correction in the calculation of standard uptake values of [18F]FDG PET.. Eur J Nucl Med 28:1326–1335PubMedCrossRefGoogle Scholar
  24. 24.
    Kim CK, Alavi JB, Alavi A, Reivich M (1991) New grading system of cerebral glioma using positron emission tomography with F-18 fluorodeoxyglucose. J Neurooncol 10:85–91PubMedCrossRefGoogle Scholar
  25. 25.
    Hustinx R, Smith RJ, Benard F, Bhatnagar A, Alavi A (1999) Can the atandardized uptake value characterize primary brain tumors on FDG-PET? Eur J Nucl Med 26:1501–1509PubMedCrossRefGoogle Scholar

Copyright information

© Academy of Molecular Imaging 2008

Authors and Affiliations

  • Tomohito Kamibayashi
    • 1
  • Tatsuro Tsuchida
    • 1
    Email author
  • Yoshiki Demura
    • 2
  • Tetsuya Tsujikawa
    • 3
  • Hidehiko Okazawa
    • 3
  • Takashi Kudoh
    • 3
  • Hirohiko Kimura
    • 1
  1. 1.Departments of Radiology, Faculty of Medical SciencesUniversity of FukuiFukuiJapan
  2. 2.Department of Respiratory Medicine, Faculty of MedicineUniversity of FukuiFukuiJapan
  3. 3.Departments of Biomedical Imaging Research CenterUniversity of FukuiFukuiJapan

Personalised recommendations