123I MIBG Mapping with Intraoperative Gamma Probe for Recurrent Neuroblastoma
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Intraoperative gamma probe guidance has become widely utilized for sentinel lymph node dissection in patients with breast cancer and melanoma, using 99mTc sulfur colloid. However, new indications are possible and need to continue to be investigated. We report the use during a wedge liver biopsy of a new hand-held gamma probe designed for 123I intraoperative guidance. The patient studied is a 5-year-old boy with history of stage 4 high-risk neuroblastoma. Anatomic imaging (CT, MRI), 99mTc bone scintigraphy and 2-deoxy-2-[F-18]fluoro-d-glucose—positron emission tomography/computed tomography (FDG-PET/CT) were negative, but the 123I MIBG scintigraphy suggested recurrent liver disease. A decision was made to biopsy these lesions to obtain histopathological confirmation. Intraoperative gamma probe mapping of the liver identified areas with signal above the background, but these were prove to be hemosiderin deposits on histo-pathology examination.
Key wordsNeuroblastoma Gamma probe Intra-operative 123I