Towards quality assurance and quality control in untargeted metabolomics studies
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We describe here the agreed upon first development steps and priority objectives of a community engagement effort to address current challenges in quality assurance (QA) and quality control (QC) in untargeted metabolomic studies. This has included (1) a QA and QC questionnaire responded to by the metabolomics community in 2015 which recommended education of the metabolomics community, development of appropriate standard reference materials and providing incentives for laboratories to apply QA and QC; (2) a 2-day ‘Think Tank on Quality Assurance and Quality Control for Untargeted Metabolomic Studies’ held at the National Cancer Institute’s Shady Grove Campus and (3) establishment of the Metabolomics Quality Assurance and Quality Control Consortium (mQACC) to drive forward developments in a coordinated manner.
KeywordsQuality assurance (QA) Quality control (QC) Community engagement Test materials Reporting metrics
All authors contributed equally to the preparation of this manuscript.
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Conflict of interest
There are no conflicts of interest to disclose. The authors declare no competing financial interests. The views presented here do not necessarily reflect those of the U.S. Food and Drug Administration. Views expressed in this article are those of the authors and do not necessarily represent views or policies of the US EPA. Mention of products or trade names does not indicate endorsement of by the US EPA. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government.
Research involving human and animal participants
No research involving human or animal participants is included.
No research involving human participants is included and no informed consent was therefore collected.
- Bowden, J. A., Heckert, A., Ulmer, C. Z., Jones, C. M., Koelmel, J. P., Abdullah, L., et al. (2017). Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using standard reference material 1950 metabolites in frozen human plasma. Journal of Lipid Research, 58(12), 2275–2288.CrossRefGoogle Scholar
- Drenos, F., Davey Smith, G., Ala-Korpela, M., Kettunen, J., Würtz, P., Soininen, P., et al. (2016). Metabolic characterization of a rare genetic variation within APOC3 and its lipoprotein lipase–independent effects. Circulation: Genomic and Precision Medicine, 9(3), 231–239.Google Scholar
- Food and Drug Administration (FDA). (2001) Guidance for industry: Bioanalytical method validation. Rockville, MD: US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and ResearchGoogle Scholar
- ISO 9000. (2015). Quality management systems—Fundamentals and vocabulary, Geneva: ISO.Google Scholar