, 12:176

Chilling slows anaerobic metabolism to improve anoxia tolerance of insects

  • Leigh Boardman
  • Jesper G. Sørensen
  • Vladimír Koštál
  • Petr Šimek
  • John S. Terblanche
Short Communication

DOI: 10.1007/s11306-016-1119-1

Cite this article as:
Boardman, L., Sørensen, J.G., Koštál, V. et al. Metabolomics (2016) 12: 176. doi:10.1007/s11306-016-1119-1



Insects are renowned for their ability to survive anoxia. Anoxia tolerance may be enhanced during chilling through metabolic suppression.


Here, the metabolomic response of insects to anoxia, both with and without chilling, for different durations (12–36 h) was examined to assess the potential cross-tolerance mechanisms.


Chilling during anoxia (cold anoxia) significantly improved survival relative to anoxia at warmer temperatures. Reduced intermediate metabolites and increased lactic acid, indicating a switch to anaerobic metabolism, were characteristic of larvae in anoxia.


Anoxia tolerance was correlated survival improvements after cold anoxia were correlated with a reduction in anaerobic metabolism.


Anoxia Hypoxia Cold Lactic acid False codling moth 

Supplementary material

11306_2016_1119_MOESM1_ESM.pdf (413 kb)
Supplementary material 1 (PDF 413 kb)

Funding information

Funder NameGrant NumberFunding Note
Czech Science Foundation
  • 13-18509S
Hortgro Stellenbosch
  • NA
Citrus Research International
  • NA

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.Department of Conservation Ecology and Entomology, Centre for Invasion BiologyStellenbosch UniversityStellenboschSouth Africa
  2. 2.Section for Genetics, Ecology & Evolution, Department of BioscienceAarhus UniversityAarhus CDenmark
  3. 3.Institute of EntomologyBiology Centre of the Czech Academy of SciencesČeské BudějoviceCzech Republic
  4. 4.Department of Entomology & NematologyUniversity of FloridaGainesvilleUSA

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