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Metabolomics

, 12:45 | Cite as

Obesity-related metabolite profiles of black women spanning the epidemiologic transition

  • Lara R. Dugas
  • Elin Chorell
  • Jacob Plange-Rhule
  • Estelle V. Lambert
  • Guichan Cao
  • Richard S. Cooper
  • Brian T. Layden
  • Denise Scholten
  • Tommy Olsson
  • Amy Luke
  • Julia H. Goedecke
Original Article

Abstract

In developed countries, specific metabolites have been associated with obesity and metabolic diseases, e.g. type 2 diabetes. It is unknown whether a similar profile persists across populations of African-origin, at increased risk for obesity and related diseases. In a cross-sectional study of normal-weight and obese black women (33.3 ± 6.3 years) from the US (N = 69, 65 % obese), South Africa (SA, N = 97, 49 % obese) and Ghana (N = 82, 33 % obese) serum metabolite profiles were characterized via gas chromatography-time of flight/mass spectrometry. In US and SA women, BMI correlated with branched-chain and aromatic amino acids, as well as dopamine and aminoadipic acid. The relationship between BMI and lipid metabolites differed by site; BMI correlated positively with palmitoleic acid (16:1) in the US; negatively with stearic acid (18:0) in SA, and positively with arachidonic acid (20:4) in Ghana. BMI was also positively associated with sugar-related metabolites in the US; i.e. uric acid, and mannitol, and with glucosamine, glucoronic acid and mannitol in SA. While we identified a common amino acid metabolite profile associated with obesity in black women from the US and SA, we also found site-specific obesity-related metabolites suggesting that the local environment is a key moderator of obesity.

Keywords

Obesity African-origin Amino acid profile 

Notes

Acknowledgments

The authors would like to acknowledge the site-specific clinic staff members as well as the 2500 participants. LRD, EC, JG all conceived the idea, performed the analyses and wrote the manuscript. JPR, EVL, AL, LD, EC all collected the data and wrote the manuscript, EC, GC, LRD and DMS performed the analyses and BTL and RC wrote the manuscript. METS is funded in part by the National Institutes of Health (1R01DK80763). The metabolomics analysis is funded by Thuringsstiftelsen.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

11306_2016_960_MOESM1_ESM.xlsx (20 kb)
Supplementary material 1 (XLSX 20 kb)
11306_2016_960_MOESM2_ESM.docx (39 kb)
Supplementary material 2 (DOCX 39 kb)

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Lara R. Dugas
    • 1
  • Elin Chorell
    • 2
  • Jacob Plange-Rhule
    • 3
  • Estelle V. Lambert
    • 4
  • Guichan Cao
    • 1
  • Richard S. Cooper
    • 1
  • Brian T. Layden
    • 5
    • 6
  • Denise Scholten
    • 5
  • Tommy Olsson
    • 2
  • Amy Luke
    • 1
  • Julia H. Goedecke
    • 7
  1. 1.Public Health Sciences, Stritch School of MedicineLoyola University ChicagoMaywoodUSA
  2. 2.Department of Public Health and Clinical MedicineUmeå UniversityUmeåSweden
  3. 3.Kwame Nkrumah University of Science and TechnologyKumasiGhana
  4. 4.Research Unit for Exercise Science and Sports MedicineUniversity of Cape TownCape TownSouth Africa
  5. 5.Division of Endocrinology, Metabolism and Molecular MedicineNorthwestern UniversityEvanstonUSA
  6. 6.Jesse Brown Veterans Affairs Medical CenterChicagoUSA
  7. 7.Non-Communicable Disease Research UnitSouth African Medical Research CouncilCape TownSouth Africa

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