, Volume 10, Issue 5, pp 1036–1041 | Cite as

1-Stearoylglycerol is associated with risk of prostate cancer: results from a serum metabolomic profiling analysis

  • Alison M. MondulEmail author
  • Steven C. Moore
  • Stephanie J. Weinstein
  • Satu Männistö
  • Joshua N. Sampson
  • Demetrius AlbanesEmail author
Short Communication


Although prostate cancer is the most commonly diagnosed cancer among men in developed populations, recent recommendations against routine prostate-specific antigen screening have cast doubt on its utility for early detection. We compared the metabolomic profiles of prospectively collected fasting serum from 74 prostate cancer cases and 74 controls selected from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort of male smokers. Circulating 1-stearoylglycerol (1-SG, or 1-monostearin) was statistically significantly inversely associated with risk of prostate cancer after Bonferroni correction for multiple comparisons (i.e., 420 identified metabolites) (OR 0.34, 95 % CI 0.20–0.58, p 6.3 × 10−5). The magnitude of this association did not differ by disease aggressiveness and was observed for cases diagnosed up to 23 years after blood collection. Similar but somewhat weaker prostate cancer risk signals were also evident for glycerol and alpha-ketoglutarate. In this population, men with higher serum 1-SG were less likely to develop prostate cancer, supporting a role for dysregulation of lipid metabolism in this malignancy. Additional studies are needed to retest the association and to examine 1-SG for its potential as a prostate cancer early detection marker.


Metabolomics Prostatic neoplasms Prospective study Nested case–control study Early detection Biomarker 



This work was supported by the Intramural Research Program of the National Cancer Institute at the National Institutes of Health (U.S. Public Health Service), and U.S. Public Health Service contracts N01-CN-45165, N01-RC-45035, N01-RC-37004, HHSN261201000006C, HHSN261200800001E.

Informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.

Supplementary material

11306_2014_643_MOESM1_ESM.pdf (665 kb)
Supplementary material 1 (PDF 665 kb)


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Copyright information

© Springer Science+Business Media New York (outside the USA)  2014

Authors and Affiliations

  • Alison M. Mondul
    • 1
    Email author
  • Steven C. Moore
    • 1
  • Stephanie J. Weinstein
    • 1
  • Satu Männistö
    • 2
  • Joshua N. Sampson
    • 3
  • Demetrius Albanes
    • 1
    Email author
  1. 1.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute, NIH, Department of Health and Human ServicesBethesdaUSA
  2. 2.Department of Chronic Disease PreventionNational Institute for Health and WelfareHelsinkiFinland
  3. 3.Biostatistics Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute, NIH, Department of Health and Human ServicesBethesdaUSA

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