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Nucleotides and nucleoside signaling in the regulation of the epithelium to mesenchymal transition (EMT)

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Abstract

The epithelium-mesenchymal transition (EMT) is an important process of cell plasticity, consisting in the loss of epithelial identity and the gain of mesenchymal characteristics through the coordinated activity of a highly regulated informational program. Although it was originally described in the embryonic development, an important body of information supports its role in pathology, mainly in cancerous and fibrotic processes. The purinergic system of inter-cellular communication, mainly based in ATP and adenosine acting throughout their specific receptors, has emerged as a potent regulator of the EMT in several pathological entities. In this context, cellular signaling associated to purines is opening the understanding of a new element in the complex regulatory network of this phenotypical differentiation process. In this review, we have summarized recent information about the role of ATP and adenosine in EMT, as a growing field with high therapeutic potential.

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Acknowledgments

We are grateful to Dr. Dorothy Pless and LCC. Jessica González Norris for editing the manuscript. This work was funded by Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica (PAPIIT-UNAM-México), number IN205114 and IN200815 to FGV-C and MD-M. ASM-R is student of Programa de Doctorado en Ciencias Biomédicas-UNAM, México and received a fellowship (number 369701) from CONACyT-México.

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  1. Departamento de Neurobiología Celular y Molecular. Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla, 3001, CP 76230, Juriquilla Querétaro, Mexico

    A. S. Martínez-Ramírez, M. Díaz-Muñoz & F. G. Vázquez-Cuevas

  2. Departamento de Biología Celular y del Desarrollo. Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 04510, México, D.F., Mexico

    A. Butanda-Ochoa

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  1. A. S. Martínez-Ramírez
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  2. M. Díaz-Muñoz
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  3. A. Butanda-Ochoa
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  4. F. G. Vázquez-Cuevas
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Correspondence to F. G. Vázquez-Cuevas.

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Angélica S. Martínez-Ramírez declares that she has no conflict of interest.

Mauricio Díaz Muñoz declares that he has no conflict of interest.

Armando Butanda-Ochoa declares that he has no conflict of interest.

Francisco G. Vázquez-Cuevas declares that he has no conflict of interest.

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Martínez-Ramírez, A.S., Díaz-Muñoz, M., Butanda-Ochoa, A. et al. Nucleotides and nucleoside signaling in the regulation of the epithelium to mesenchymal transition (EMT). Purinergic Signalling 13, 1–12 (2017). https://doi.org/10.1007/s11302-016-9550-3

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