Purinergic Signalling

, Volume 8, Issue 3, pp 343–357 | Cite as

ATP synthesis and storage

  • Massimo Bonora
  • Simone Patergnani
  • Alessandro Rimessi
  • Elena De Marchi
  • Jan M. Suski
  • Angela Bononi
  • Carlotta Giorgi
  • Saverio Marchi
  • Sonia Missiroli
  • Federica Poletti
  • Mariusz R. Wieckowski
  • Paolo PintonEmail author
Original Article


Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell metabolism revolve around ATP production and consumption. It is important to understand the concepts of glucose and oxygen consumption in aerobic and anaerobic life and to link bioenergetics with the vast amount of reactions occurring within cells. ATP is universally seen as the energy exchange factor that connects anabolism and catabolism but also fuels processes such as motile contraction, phosphorylations, and active transport. It is also a signalling molecule in the purinergic signalling mechanisms. In this review, we will discuss all the main mechanisms of ATP production linked to ADP phosphorylation as well the regulation of these mechanisms during stress conditions and in connection with calcium signalling events. Recent advances regarding ATP storage and its special significance for purinergic signalling will also be reviewed.


ATP synthesis ATP storage Mitochondria Calcium 



The authors apologize for any excessive bias and the inevitable omissions. The authors are also deeply indebted to past collaborators. This research was supported by the Ministry of Science and Higher Education, Poland, grant NN407 075 137 to MRW; the Italian Ministry of Health to A.R.; and the Italian Association for Cancer Research (AIRC), Telethon (GGP09128), local funds from the University of Ferrara, the Italian Ministry of Education, University and Research (COFIN, FIRB and Futuro in Ricerca), the Italian Cystic Fibrosis Research Foundation, and Italian Ministry of Health to P.P.

SM was supported by a FIRC fellowship; AB was supported by a research fellowship Fondazione Italiana Sclerosi Multipla (FISM)-Cod. 2010/B/1; SP was supported by a training fellowship FISM-Cod. 2010/B/13; JMS was supported by PhD fellowship from The Foundation for Polish Science (FNP), UE, European Regional Development Fund and Operational Programme “Innovative economy”.


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© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Massimo Bonora
    • 1
  • Simone Patergnani
    • 1
  • Alessandro Rimessi
    • 1
  • Elena De Marchi
    • 1
  • Jan M. Suski
    • 1
    • 2
  • Angela Bononi
    • 1
  • Carlotta Giorgi
    • 1
  • Saverio Marchi
    • 1
  • Sonia Missiroli
    • 1
  • Federica Poletti
    • 1
  • Mariusz R. Wieckowski
    • 2
  • Paolo Pinton
    • 1
    Email author
  1. 1.Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI), Laboratory for Technologies of Advanced Therapies (LTTA)University of FerraraFerraraItaly
  2. 2.Nencki Institute of Experimental BiologyWarsawPoland

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