Expression of P2X2 and P2X3 receptors in the rat carotid sinus, aortic arch, vena cava, and heart, as well as petrosal and nodose ganglia
- First Online:
- 142 Downloads
With single- and double-labeling immunofluorescence techniques, the distribution patterns and morphological characteristics of P2X2- and P2X3-immunoreactive nerve fiber terminals and neuronal bodies have been studied in the main circulatory system baroreceptors and the nodose and petrosal ganglia of rats. A high density of P2X2- and P2X3-immunoreactive nerve fiber terminals was detected in the carotid sinus. P2X2- and P2X3-immunoreactive nerve fiber terminals were also distributed widely in the aortic arch, atrium, vena cava, and ventricles. Almost all the P2X2-immunoreactive nerve fiber terminals were immunoreactive for P2X3 receptors. P2X2- and P2X3-immunoreactive neuronal bodies were also detected in the nodose and petrosal ganglia, which are the sources of the P2X2- and P2X3-immunoreactive nerve terminals. P2X2 and P2X3 receptors were expressed in the same ganglionic neurons. These data indicate that extracellular ATP, via the homomeric P2X2 and P2X3 receptors, and heteromeric P2X2/3 receptor in the sensory receptors of carotid sinus, aortic arch, atrium, and vena cava, may be involved in the regulation of systematic circulation blood pressure.
KeywordsPurinoceptor Baroreceptor Immunohistochemistry Rat
- 15.Cockayne DA, Hamilton SG, Zhu QM, Dunn PM, Zhong Y, Novakovic S, Malmberg AB, Cain G, Berson A, Kassotakis L, Hedley L, Lachnit WG, Burnstock G, McMahon SB, Ford AP (2000) Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407:1011–1015PubMedCrossRefGoogle Scholar
- 19.Cars well F, Hainsworth R, Ledsome JR (1968) The effects of varying pressures in the aortic arch on limb resistance and heart rate. J Physiol 196:38–39Google Scholar