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Purinergic Signalling

, Volume 7, Issue 3, pp 357–365 | Cite as

Adenosine and blood platelets

  • Hillary A. Johnston-Cox
  • Katya Ravid
Review

Abstract

Adenosine is an important regulatory metabolite and an inhibitor of platelet activation. Adenosine released from different cells or generated through the activity of cell-surface ectoenzymes exerts its effects through the binding of four different G-protein-coupled adenosine receptors. In platelets, binding of A2 subtypes (A2A or A2B) leads to consequent elevation of intracellular cyclic adenosine monophosphate, an inhibitor of platelet activation. The significance of this ligand and its receptors for platelet activation is addressed in this review, including how adenosine metabolism and its A2 subtype receptors impact the expression and activity of adenosine diphosphate receptors. The expression of A2 adenosine receptors is induced by conditions such as oxidative stress, a hallmark of aging. The effect of adenosine receptors on platelet activation during aging is also discussed, as well as potential therapeutic applications.

Keywords

Adenosine A2B adenosine receptor A2A adenosine receptor ADP-mediated platelet activation and aggregation Cyclic adenosine monophosphate (cAMP) 

Notes

Acknowledgments

This work was supported by NHLBI grant HL93149 to KR. KR is an Established Investigator with the AHA. We apologize to colleagues for potentially not citing other papers because of space constrains.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Departments of Medicine and Biochemistry, Whitaker Cardiovascular Institute, and Evans Center for Interdisciplinary Biomedical ResearchBoston University School of Medicine, CVIBostonUSA

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