Purinergic Signalling

, 5:197 | Cite as

The P2X7 receptor and intracellular pathogens: a continuing struggle

  • Robson Coutinho-Silva
  • Gladys Corrêa
  • Ali Abdul Sater
  • David M. Ojcius
Review

Abstract

The purinergic receptor, P2X7, has recently emerged as an important component of the innate immune response against microbial infections. Ligation of P2X7 by ATP can stimulate inflammasome activation and secretion of proinflammatory cytokines, but it can also lead directly to killing of intracellular pathogens in infected macrophages and epithelial cells. Thus, while some intracellular pathogens evade host defense responses by modulating with membrane trafficking or cell signaling in the infected cells, the host cells have also developed mechanisms for inhibiting infection. This review will focus on the effects of P2X7 on control of infection by intracellular pathogens, microbial virulence factors that interfere with P2X7 activity, and recent evidence linking polymorphisms in human P2X7 with susceptibility to infection.

Keywords

Apoptosis PLD Ecto-ATPases Purinergic receptors ATP SNPs 

Abbreviations

NDK

nucleoside diphosphate kinase

NTPase

nucleoside triphosphatase

PLD

phospholipase D

ROS

reactive oxygen species

SNP

single nucleotide polymorphisms

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Robson Coutinho-Silva
    • 1
    • 3
  • Gladys Corrêa
    • 1
  • Ali Abdul Sater
    • 2
  • David M. Ojcius
    • 2
  1. 1.Immunobiology Program, Biophysics Institute Carlos Chagas FilhoFederal University of Rio de JaneiroRJBrazil
  2. 2.School of Natural SciencesUniversity of CaliforniaMercedUSA
  3. 3.Instituto de Biofísica Carlos Chagas Filho – UFRJCidade UniversitáriaIlha do FundãoBrazil

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