Ecological Research

, Volume 26, Issue 6, pp 1017–1026

Evolution of virulence, environmental change, and the threat posed by emerging and chronic diseases

Special Feature Environmental change, pathogens and human linkages


Assessments of future threats posed by infection have focused largely on zoonotic, acute disease, under the rubric “emerging diseases.” Evolutionary and epidemiological studies indicate, however, that particular aspects of infrastructure, such as protected water supplies, vector-proof housing, and health care facilities, protect against the emergence of zoonotic, acute infectious diseases. While attention in the global health community has focused on emerging diseases, there has been a concurrent, growing recognition that important chronic diseases, such as cancer, are often caused by infectious agents that are already widespread in human populations. For economically prosperous countries, the immediacy of this threat contrasts with their infrastructural protection from severe acute infectious disease. This reasoning leads to the conclusion that chronic infectious diseases pose a more significant threat to economically prosperous countries than zoonotic, acute infectious diseases. Research efforts directed at threats posed by infection may therefore be more effective overall if increased efforts are directed toward understanding and preventing infectious causes of chronic diseases across the spectrum of economic prosperity, as well as toward specific infrastructural improvements in less prosperous countries to protect against virulent, acute infectious diseases.


Evolution Virulence Transmission Emerging diseases Infection 


  1. Abdel-Aziz HO, Murai Y, Hong M, Kutsuna T, Takahashi H, Nomoto K, Murata S, Tsuneyama K, Takano Y (2007) Detection of the JC virus genome in lung cancers: possible role of the T-antigen in lung oncogenesis. Appl Immunohistochem Mol Morphol 15:394–400PubMedCrossRefGoogle Scholar
  2. Arisawa K, Soda M, Ono M, Uemura H, Hiyoshi M, Suyama A (2009) Trends of incidence rate of adult T-cell leukemia/lymphoma in an HTLV-1 endemic area in Japan. Int J Cancer 125:737–738PubMedCrossRefGoogle Scholar
  3. Burnet FM, Clark E (1942) Influenza: a survey of the last 50 years in the light of modern work on the virus of epidemic influenza. Macmillan, MelbourneGoogle Scholar
  4. Byerly CR (2005) Fever of war. The influenza epidemic in the US Army during World War I. New York University Press, New YorkGoogle Scholar
  5. Centers for Disease Control (1996) Dengue fever at the US-Mexico border, 1995–1996. Morb Mortal Wkly Rep 45:841–844Google Scholar
  6. Centers for Disease Control (2002) Influenza outbreak—Madagascar, July–August 2002. MMWR Morb Mortal Wkly Rep 51:1016–1018Google Scholar
  7. Eliades MJ et al (2005) Malaria surveillance—United States, 2003. MMWR Surveill Summ 54:25–40PubMedGoogle Scholar
  8. Epstein PR (2000) Is global warming harmful to health? Sci Am 283:50–57PubMedCrossRefGoogle Scholar
  9. Ewald PW (1983) Host parasite relations, vectors and the evolution of disease severity. Annu Rev Ecol Syst 14:465–485CrossRefGoogle Scholar
  10. Ewald PW (1988) Cultural vectors, virulence, and the emergence of evolutionary epidemiology. Oxf Surv Evol Biol 5:215–244Google Scholar
  11. Ewald PW (1991a) Waterborne transmission of gastrointestinal bacteria and the evolution of virulence. Epidemiol Infect 106:83–119PubMedCrossRefGoogle Scholar
  12. Ewald PW (1991b) Culture, transmission modes and the evolution of virulence, with special reference to cholera, influenza, and AIDS. Hum Nat 2:1–30CrossRefGoogle Scholar
  13. Ewald PW (1994) Evolution of infectious disease. Oxford University Press, New YorkGoogle Scholar
  14. Ewald PW (2002) Plague time. The new germ theory of disease. Anchor, New YorkGoogle Scholar
  15. Ewald PW (2009) An evolutionary perspective on parasitism as a cause of cancer. Adv Parasitol 68:21–43Google Scholar
  16. Garrett L (1994) The coming plague. Newly emerging diseases in a world out of balance. Farrar, Straus and Giroux, NYGoogle Scholar
  17. Gorman OT, Bean WJ, Kawaoka Y, Donatelli I, Guo YJ, Webster RG (1991) Evolution of influenza A virus nucleoprotein genes: implications for the origins of H1N1 human and classical swine viruses. J Virol 65:3704–3714PubMedGoogle Scholar
  18. Holmes EC (2001) On the origin and evolution of the human immunodeficiency virus (HIV). Biol Rev Camb Philos Soc 76:239–254PubMedCrossRefGoogle Scholar
  19. Khasnis AA, Nettleman MD (2005) Global warming and infectious disease. Arch Med Res 36:689–696PubMedCrossRefGoogle Scholar
  20. Lafferty KD (2009) The ecology of climate change and infectious diseases. Ecology 90:888–900PubMedCrossRefGoogle Scholar
  21. Lautze J, McCartney M, Kirshen P, Olana D, Jayasinghe G, Spielman A (2007) Effect of a large dam on malaria risk: the Koka reservoir in Ethiopia. Trop Med Int Health 12:982–989Google Scholar
  22. Markov PV, Pepin J, Frost E, Deslandes S, Labbe AC, Pybus OG (2009) Phylogeography and molecular epidemiology of hepatitis C virus genotype 2 in Africa. J Gen Virol 90:2086–2096PubMedCrossRefGoogle Scholar
  23. McMichael AJ, Woodruff RE, Hales S (2006) Climate change and human health: present and future risks. Lancet 367:859–869PubMedCrossRefGoogle Scholar
  24. Morens DM, Taubenberger JK, Fauci AS (2009) The persistent legacy of the 1918 influenza virus. N Engl J Med 361:225–229PubMedCrossRefGoogle Scholar
  25. Morse SS (ed) (1993) Emerging viruses. Oxford University Press, New YorkGoogle Scholar
  26. Olson DR, Simonsen L, Edelson PJ, Morse SS (2005) Epidemiological evidence of an early wave of the 1918 influenza pandemic in New York City. Proc Natl Acad Sci USA 102:11059–11063PubMedCrossRefGoogle Scholar
  27. Plamondon M, Labbe AC, Frost E, Deslandes S, Alves AC, Bastien N, Pepin J (2007) Hepatitis C virus infection in Guinea-Bissau: a sexually transmitted genotype 2 with parenteral amplification? PLoS One 2:e372PubMedCrossRefGoogle Scholar
  28. Preston R (1994) The Hot Zone. Random House, New YorkGoogle Scholar
  29. Rambaut A, Robertson DL, Pybus OG, Peeters M, Holmes EC (2001) Human immunodeficiency virus. Phylogeny and the origin of HIV-1. Nature 410:1047–1048PubMedCrossRefGoogle Scholar
  30. Reiter P et al (2003) Texas lifestyle limits transmission of dengue virus. Emerg Infect Dis 9:86–89PubMedGoogle Scholar
  31. Solomon T, Mallewa M (2001) Dengue and other emerging flaviviruses. J Infect 42:104–115PubMedCrossRefGoogle Scholar
  32. Terrault NA (2002) Sexual activity as a risk factor for hepatitis C. Hepatology 36:S99–S105PubMedCrossRefGoogle Scholar
  33. Urbanus AT, van de Laar TJ, Stolte IG, Schinkel J, Heijman T, Coutinho RA, Prins M (2009) Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS 23:F1–F7PubMedCrossRefGoogle Scholar
  34. Viboud C, Tam T, Fleming D, Miller MA, Simonsen L (2006) 1951 influenza epidemic, England and Wales, Canada, and the United States. Emerg Infect Dis 12:661–668PubMedGoogle Scholar
  35. Walther BA, Ewald PW (2004) Pathogen survival in the external environment and the evolution of virulence. Biol Rev 79:849–869PubMedCrossRefGoogle Scholar
  36. Watson RB (1949) Location and mosquito proofing of dwellings. In: Boyd MF (ed) Malariology. Saunders, Philadelphia, pp 1184–1202Google Scholar
  37. Weissman JB, Marton KI, Lewis JN, Friedmann CT, Gangarosa EJ (1974) Impact in the United States of the Shiga dysentery pandemic of Central America and Mexico: a review of surveillance data through 1972. J Infect Dis 129:218–223PubMedCrossRefGoogle Scholar
  38. WHO-GOARN Investigation Team (2002) Outbreak of influenza, Madagascar, July–August 2002. Euro Surveill 7:172–174Google Scholar
  39. Wilson ML (1994) Rift Valley fever virus ecology and the epidemiology of disease emergence. Ann N Y Acad Sci 740:169–180PubMedCrossRefGoogle Scholar
  40. World Health Organization (2004) Avian influenza A(H5N1)—update 31: situation (poultry) in Asia: need for a long-term response, comparison with previous outbreaks.
  41. World Health Organization (2009a) Cancer. (
  42. World Health Organization (2009b) H5N1 avian influenza: timeline of major events. Accessed 27 July 2009
  43. Worobey M et al (2008) Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960. Nature 455:661–664PubMedCrossRefGoogle Scholar
  44. Zell R (2004) Global climate change and the emergence/re-emergence of infectious diseases. Int J Med Microbiol 293(Suppl 37):16–26PubMedGoogle Scholar
  45. Zheng H, Abdel Aziz HO, Nakanishi Y, Masuda S, Saito H, Tsuneyama K, Takano Y (2007) Oncogenic role of JC virus in lung cancer. J Pathol 212:306–315PubMedCrossRefGoogle Scholar
  46. Zimmer SM, Burke DS (2009) Historical perspective—emergence of influenza A (H1N1) viruses. N Engl J Med 361:279–285PubMedCrossRefGoogle Scholar
  47. zur Hausen H (2006) Infections causing human cancer. Wiley-VCH, WeinheimCrossRefGoogle Scholar

Copyright information

© The Ecological Society of Japan 2011

Authors and Affiliations

  1. 1.Department of Biology and the Program on Disease EvolutionUniversity of LouisvilleLouisvilleUSA

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