Oral Radiology

, 24:55 | Cite as

99mTc-MDP bone uptake in secondary hyperparathyroidism: comparison of the mandible, cranium, radius, and femur

  • Edson Boasquevisque
  • Jorge Wagner Esteves da Silva
  • Vanessa V. de Albuquerque Bernardo
  • Sara Mello Santana de Macedo
  • Camila S. Boasquevisque
  • André Ribeiro Nogueira de Oliveira
  • Erika Tami Pires Kasai
  • Carlos A. Mandarim-de-Lacerda
Original Article
First Online:
Received:
Accepted:

Abstract

Objectives

To evaluate the bone involvement of the mandible, cranium, radius, and femur in secondary hyperparathyroidism (SHPT) using 99mTc-MDP uptake correlated with the serum intact parathyroid hormone (PTHi).

Methods

In a prospective study of 54 patients with SHPT due to chronic renal disease and 15 normal individuals (control group), all patients had elevated serum PTHi and positive 99mTc-MDP bone scintigraphy. Bone uptake was measured in regions of interest (ROIs) in the mandible, posterior cranium, distal radius, and proximal femur. In addition, soft tissue uptake was measured in one ROI in the soft tissues of the medial thigh (BG). The ROI-BG ratio was used as an index of the normalized bone uptake.

Results

The uptake differences in the SHPT and control groups were statistically significant for the mandible (P = 0.001) and cranium (P = 0.002). When the SHPT group was subclassified according to serum PTHi levels, the bone uptake increased with the serum PTHi level. All mandibles of the patients with SHPT were abnormal, and 33% had focal lesions.

Conclusions

The bone uptake in the SHPT group was abnormal in all areas evaluated, and a high uptake of 99mTc-MDP was correlated with an increased serum PTHi.

Key words

Secondary hyperparathyroidism Scintigraphy 99mTc-MDP Mandible 
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Copyright information

© Japanese Society for Oral and Maxillofacial Radiology and Springer Japan 2008

Authors and Affiliations

  • Edson Boasquevisque
    • 1
  • Jorge Wagner Esteves da Silva
    • 2
  • Vanessa V. de Albuquerque Bernardo
    • 3
  • Sara Mello Santana de Macedo
    • 3
  • Camila S. Boasquevisque
    • 4
  • André Ribeiro Nogueira de Oliveira
    • 3
  • Erika Tami Pires Kasai
    • 3
  • Carlos A. Mandarim-de-Lacerda
    • 1
  1. 1.Laboratório de Medicina Nuclear Experimental, Departamento de AnatomiaInstituto de Biologia Roberto Alcântara GomesRio de JaneiroBrasil
  2. 2.Departamento de Patologia e Laboratórios, Faculdade de Ciências MédicasUniversidade do Estado do Rio de JaneiroJaneiroBrasil
  3. 3.Serviço de Medicina Nuclear, Hospital Universitário Pedro ErnestoUniversidade do Estado do Rio de JaneiroJaneiroBrasil
  4. 4.Faculdade de OdontologiaUniversidade do Estado do Rio de JaneiroJaneiroBrasil

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