Oral Radiology

, Volume 21, Issue 1, pp 14–18

Micro-computed tomography newly developed for in vivo small animal imaging

  • Yoshinori Arai
  • Ayuta Yamada
  • Tadashi Ninomiya
  • Takafumi Kato
  • Yuji Masuda
ORIGINAL ARTICLE

Abstract

Objectives

The aim of this paper is to report a newly developed micro-computed tomography system for in vivo use.

Methods

The system was composed of a micro-focus X-ray tube and an image intensifier (I.I.), both of which rotated around the object stage. A guinea pig and a rat were examined. The anesthetized animal was set on the secure object stage. Images of the head of the guinea pig and the tibia/knee joint of the rat were taken. In addition, an image of the rat’s tail was taken. The reconstruction and the image viewing were carried out using I-View software.

Results

The voxel matrix was 512 × 512 × 384. The voxel sizes ranged from 10 × 10 × 10 µm to 100 × 100 × 100 µm. The exposure time was 17 s, and the reconstruction time was 150 s. The head of the guinea pig and the tibia/knee joint of the rat were observed clearly under 100-µm and 30-µm voxels, respectively. The trabecular bone of the tail was also observed clearly under a 10-µm voxel.

Conclusions

The newly developed micro-computed tomography system makes it possible to obtain images of anesthetized animals set on a secure object stage. Clear bone images of the small animals could be obtained within a short time.

Key words

Micro-computed tomography In vivo Bone structure 

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Copyright information

© Japanese Society for Oral and Maxillofacial Radiology Springer-Verlag Tokyo 2005

Authors and Affiliations

  • Yoshinori Arai
    • 1
  • Ayuta Yamada
    • 2
  • Tadashi Ninomiya
    • 1
  • Takafumi Kato
    • 1
  • Yuji Masuda
    • 1
  1. 1.Institute for Oral ScienceMatsumoto Dental UniversityNaganoJapan
  2. 2.Rigaku Mechatronics Co., Ltd.TokyoJapan

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