Insect microbial symbionts as a novel source for biotechnology
Insecta is the most diverse and largest class of animals on Earth, appearing together with the emergence of the first terrestrial ecosystem. Owing to this great diversity and long-term coexistence, an amazing variety of symbiotic microorganisms have adapted specifically to insects as hosts. Insect symbionts not only participate in many relationships with the hosts but also represent a novel resource for biotechnological applications. The exploitation of mutualistic symbiosis represents a promising area to search for bioactive compounds and new enzymes for potential clinical, industrial or environmental applications. Moreover, the manipulation of parasitic symbiosis has particular potential to solve practical problems for the control of agricultural pests and disease vectors. Although the study of microbial symbionts has been impaired by the unculturability of most symbionts, the rapidly growing catalogue of microbial genomes and the application of modern genetic techniques provide an alternative approach to using these microbes. This minireview presents examples of microbial symbionts isolated from insects for emerging biotechnological use and illuminates new ways for discovering microorganisms of applied value from a particularly promising source.
KeywordsBioactive compounds Insect Metabolites Microbiome Symbionts
We sincerely thank Dr. Ian Maddox for the invitation and encouragement to submit this paper. We also thank the editor and four anonymous reviewers for insightful comments on the manuscript, and we gratefully acknowledge the National Natural Science Foundation of China (Grant No. 31601906), the Modern Agricultural Industry Technology System (Grant No. CARS-18-ZJ0302), Zhejiang province analysis and testing science and technology project (Grant No. 2018C37060) and Max Planck Society for their financial support in our work.
- Daisley BA, Trinder M, McDowell TW, Collins SL, Sumarah MW, Reid G (2018) Microbiota-mediated modulation of organophosphate insecticide toxicity by species-dependent interactions with lactobacilli in a drosophila melanogaster Insect Model. Appl Environ Microbiol 84:e02820–e02817CrossRefGoogle Scholar
- Otagiri M, Lopez CM, Kitamoto K, Arioka M, Kudo T, Moriya S (2013) Heterologous expression and characterization of a glycoside hydrolase family 45 endo-beta-1,4-glucanase from a symbiotic protist of the lower termite, Reticulitermes speratus. Appl Biochem Biotechnol 169:1910–1918CrossRefGoogle Scholar
- Zhang D, Lees RS, Xi Z, Gilles JR, Bourtzis K (2015a) Combining the sterile insect technique with wolbachia-based approaches: II–A safer approach to aedes albopictus population suppression programmes, designed to minimize the consequences of inadvertent female release. PLoS ONE 10:e0135194CrossRefGoogle Scholar
- Zhang D, Lees RS, Xi Z, Bourtzis K, Gilles JR (2016) Combining the sterile insect technique with the incompatible insect technique: III-robust mating competitiveness of irradiated triple wolbachia-infected aedes albopictus males under semi-field conditions. PLoS ONE 11:e0151864CrossRefGoogle Scholar