The combination of osthole with baicalin protects mice from Staphylococcus aureus pneumonia
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We reported the inhibition of α-Hemolysin (Hla) production in methicillin-resistant Staphylococcus aureus USA300 by osthole and further investigated the combination of osthole and baicalin in the treatment of staphylococcal pneumonia. Using cytotoxicity assays and a mouse model of intranasal lung infection, we evaluated the effect of combined therapy. Our results suggest that the combination of osthole and baicalin alleviated S. aureus-mediated A549 cell injury and protected mice from S. aureus pneumonia.
KeywordsStaphylococcus aureus Osthole Baicalin Alpha-hemolysin
This work was supported by the National Basic Research Program of China (Grant 2013CB127205), the National Nature Science Foundation of China (Grant 31130053) and the National 863 program (Grant 2012AA020303).
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Conflicts of interest
The authors declare no conflict of interest.
The animal studies were performed according to the Regulations for the Administration of Affairs Concerning Experimental Animals (1988.11), and all experimental protocols were approved by the Institutional Animal Care and Use Committee (IACUC) of Jilin University.
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