Antifouling and antibacterial compounds from a marine fungus Cladosporium sp. F14

  • Shu-Hua Qi
  • Ying Xu
  • Hai-Rong Xiong
  • Pei-Yuan Qian
  • Si Zhang
Original Paper

DOI: 10.1007/s11274-008-9904-2

Cite this article as:
Qi, SH., Xu, Y., Xiong, HR. et al. World J Microbiol Biotechnol (2009) 25: 399. doi:10.1007/s11274-008-9904-2

Abstract

To investigate the antifouling secondary metabolites from marine-derived fungi, we used bioassay-guided column chromatography techniques, such as HPLC, to separate and purify compounds from Cladosporium sp. F14. Extensive spectral analyses including 1D NMR spectra and MS were employed for structure elucidation of the compounds. Antilarval activity of the compounds was evaluated in settlement inhibition assays with laboratory-reared Balanus amphitrite and Bugula neritina larvae, while antibacterial activity was assessed with disc diffusion bioassay on growth inhibition of six marine bacterial species. In total, nine compounds were obtained. Among them, 3-phenyl-2-propenoic acid, cyclo-(Phe-Pro) and cyclo-(Val-Pro) had various antibacterial activities against three fouling bacteria, furthermore, 3-phenyl-2-propenoic acid and bis(2-ethylhexyl)phthalate effectively inhibited larval settlement of B. neritina and B. amphitrite larvae, respectively, indicating that the two compounds are potential natural antifouling agents.

Keywords

Marine fungus Antifouling Antibacterial Compounds Cladosporium sp. 

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Shu-Hua Qi
    • 1
  • Ying Xu
    • 2
  • Hai-Rong Xiong
    • 3
  • Pei-Yuan Qian
    • 2
  • Si Zhang
    • 1
  1. 1.Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of OceanologyThe Chinese Academy of SciencesGuangzhouPeople’s Republic of China
  2. 2.Coastal Marine Laboratory, Department of BiologyHong Kong University of Science and TechnologyHong Kong SARPeople’s Republic of China
  3. 3.South-Central University for NationalitiesWuhanPeople’s Republic of China

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