A novel separation technique based on an aqueous surfactant extraction to remove organic contaminants from aqueous solutions was investigated. A model was developed regarding the kinetic partitioning of amoxicillin and regarding the mechanism governing the forward transfer of amoxicillin in a reverse micelle system. Results were interpreted in terms of a two-film theory for flat interface. To confirm the relevance of the developed separation technique, it was applied to the elimination of amoxicillin by adsorption on an anionic surfactant, sodium dodecyl sulfate. The effects of various parameters such as contact time, pH, temperature, and initial concentration of sodium dodecyl sulfate were investigated at an agitation speed of 350 rpm. The percentage of maximum adsorption capacity of amoxicillin was found to be 87.7 % for the following optimal conditions: amoxicillin concentration of 4 mg/L, 40 min contact time, pH 4, 50 °C, and 0.01 g/L initial sodium dodecyl sulfate concentration. The results showed that the pseudo-first-order model provides most adequate correlation of experimental data compared to the pseudo-second-order model. Three statistical functions were used to estimate the error deviations between experimental and theoretically predicted kinetic adsorption values, including the average relative error deviation (ARED), the sum of the squares of the errors (SSE), and the standard deviation of residuals (S res). The results showed that, both Freundlich equation and pseudo-first-order equation provide the best fit to experimental data. Adsorption isotherm data appeared to be accurately described by a Freundlich model. The thermodynamic parameters (∆G, ∆H, and ∆S) showed that the process was feasible, spontaneous, and exothermic.
This is a preview of subscription content, log in to check access.
Buy single article
Instant access to the full article PDF.
Price includes VAT for USA
Subscribe to journal
Immediate online access to all issues from 2019. Subscription will auto renew annually.
This is the net price. Taxes to be calculated in checkout.
- A :
total interfacial area between the two phases (m2)
- C 1 * :
concentration of phase 1 at interface (g/L)
- C 2 * :
concentration of phase 2 at interface (g/L)
- C 1 :
concentration of phase 1 (g/L)
- C 2 :
concentration of phase 2 (g/L)
- J :
mass transfer rate (g/s)
- K :
overall mass transfer coefficient (m/s)
- K aq A :
individual aqueous phase mass transfer coefficient (m3/s)
- K m A :
individual micellar phase mass transfer coefficient (m3/s)
- KA :
combined mass transfer coefficient (m3/s)
- m :
equilibrium partition coefficient
amount of amoxicillin adsorbed per g of sorbent (mg/g)
- V 1 :
volume of phase 1 (m3)
- V 2 :
volume of phase 2 (m3)
- V r :
phase volume ratio
- α :
first model parameter (s−1)
- β :
second model parameter (−)
Adriano, W. S., Veredas, V., Santana, C. C., & Goncalves, L. R. B. (2005). Adsorption of amoxicillin on chitosan beads: kinetics, equilibrium and validation of finite batch models. Biochemical Engineering Journal, 27, 132–137.
Aksu, Z. (2002). Determination of the equilibrium, kinetic and thermodynamic parameters of the batch adsorption of nickel(II) ions onto Chlorella vulgaris. Process Biochemestry, 38, 89–99.
Avisar, D., Primor, O., Gozlan, I., & Mamane, H. (2010). Sorption of sulfonamides and tetracyclines to montmorillonite clay. Water, Air, & Soil Pollution, 209(1–4), 439–450.
Buchberger, W. (2011). Current approaches to trace analysis of pharmaceuticals an personal care products in the environment. Journal of Chromatography A, 1218, 603–618.
Edwards, D. A., Adeel, Z., & Luthy, R. G. (1994). Distribution of nonionic surfactant an phenanthrene in a sediment/aqueous system. Environmental Science Technology, 28, 1550–1560.
Erdinc, N., Gokturk, S., & Tuncay, M. (2010). A study on the adsorption characteristics an amphiphilic phenothiazine drug on activated charcoal in the presence surfactants. Colloids and Surfaces B, 75, 194–203.
Figueroa, R. A., & Mackay, A. A. (2005). Sorption of oxytetracycline to iron oxides an iron oxide-rich soils. Environmental Science Technolology, 39, 6664–6671.
Gemeay, A. H. (2002). Adsorption characteristics and the kinetics of the cation exchange of rhodamine-6G with Naþ-montmorillonite. Journal of Colloid Interface Sciences, 251, 235–241.
Gengec, E., Ozdemir, U., Ozbay, B., Ozbay, I., & Veli, S. (2013). Optimizing dye adsorption onto a waste-derived (modifiedcharcoal ash) adsorbent using Box–Behnken and central composite design procedures. Water, Air, & Soil Pollution, 224(10), 1–12.
Goto, M., Ishikawa, Y., Ono, T., Nakashio, F., & Hatton, T. A. (1998). Extraction and activity of chymotrypsin using AOT-DOLPA mixed reversed micellar systems. Biotechnology Progress, 14, 729–734.
Hamdaoni, O., & Chiha, M. (2007). Removal of methylene blue from aqueous solution by wheat bran. Acta Chimica Slovenica, 54, 407–418.
Hatton, T. A. (1985). Liquid–liquid extraction of proteins. In M. M. Young (Ed.), Comprehensive biotechnology II. United States of America: Pergamon Press.
Kolpin, D. W., Furlong, E. T., Meyer, M. T., Thurman, E. M., Zaugg, S. D., & Barber, L. B. (2002). Pharmaceuticals, hormones, and other organic wastewater contaminants in US streams, 1999-2000: a national reconnaissance. Environmental Science and Technology, 36, 1202–1211.
Lagergren, S. (1898). About the theory of so-called adsorption of soluble substances. Kungliga Svenska Vetenskapsakademiens Handlingar, 24, 1–39.
Li, J., Chen, S., Sheng, G., Hu, J., Tan, X., & Wang, X. (2011). Effect of surfactants on Pb(II) adsorption from aqueous solutions using oxidized multiwall carbon nanotubes. Chemical Engineering Journal, 166, 551–558.
Lin, S. H., & Juang, R. S. (2009). Adsorption of phenol and its derivatives from water using synthetic resins and low-cost natural adsorbents: a review. Journal of Environmental Management, 90, 1336–1349.
Marzieh, S., Demneh, G., Nasernejad, B., & Modarres, H. (2011). Modeling investigation of membrane biofouling phenomena by considering the adsorption of protein, polysaccharide and humic acid. Colloids and Surfaces B: Biointerfaces, 88, 108–114.
Mishra, V., Balomajumder, C., & Agarwal, V. K. (2012). Kinetics, mechanistic and thermodynamics of Zn(II) Ion sorption: a modeling approach. Clean: Soil, Air, Water, 40(7), 718–727.
Mohd-Setapar, S. H., Lau, S. W., Yong, C., Chen, P. L., Shanjingm, Y., & Mat, H. (2008a). Partitioning behaviour of selected antibiotics in organic solvents. Journal of Chemical and Natural Resources Engineering, 2(Special), 100–112.
Mohd-Setapar, S. H., Lau, S. W., Toorisaka, E., Goto, M., Furusaki, S., & Mat, H. (2008b). Reverse micelle extraction of antibiotics. Jurnal Teknologi F, 49F, 69–79.
Mohd-Setapar, S. H., Wakeman, R. J., & Tarleton, E. S. (2009). Penicillin G solubilisation into AOT reverse micelles. Chemical Engineering Research and Design, 87, 833–842.
Oleszczuk, P., Pan, B., & Xing, B. (2009). Adsorption and desorption of oxytetracycline and carbamazepine by multiwalled carbon nanotubes. Environmental Science Technolology, 43, 9167–9173.
Ono, T., Goto, M., Nakashio, F., & Hatton, T. A. (1996). Extraction behaviour of haemoglobin using reversed micelles by dioleyl phosphoric acid. Biotechnology Progress, 12, 793–800.
Özbay, I., Özbay, U., Bilge, O., & Sevil, V. (2013). Kinetic, thermodynamic, and equilibrium studies for adsorption of azo reactive dye onto a novel waste adsorbent: charcoal ash. Desalination and Water Treatment, 51, 6091–6100.
Pan, B., Ning, P., & Xing, B. (2009). Part V sorption of pharmaceuticals and personal care products. Environmental Science and Pollution Research, 16, 106–116.
Paradkar, V. M., & Dordick, S. (1994). Affinity-based reverse micellar extraction and separation (ARMES): a facile technique for the purification of peroxidase from soybean hulls. Biotechnology Progress, 9, 199–203.
Riahi, K., Chaabane, S., Ben Thayer, B. (2013). A kinetic modeling study of phosphate adsorption onto Phoenix dactylifera L. date palm fibers in batch mode. Journal of Saudi Chemical Society in press.
Shuang, X. Z., Yan, Z., Xiaoying, J., & Zuliang, C. (2013). The removal of amoxicillin from wastewater using organobentonite. Journal of Environmental Management, 129, 569–576.
Siti, H., Mohd-Setapar, H. S., Hanapi, M., & Siti, N. M. (2012). Kinetic study of antibiotic by reverse micelle extraction technique. Journal of the Taiwan Institute of Chemical Engineers, 43(5), 685–695.
Wang, S., Wei, J., Shasha, L., Guo, Z., & Jiang, F. (2013). Removal of organic dyes in environmental water onto magnetic-sulfonic grapheme nanocomposite. Clean: Soil, Air, Water, 41(10), 992–1001.
Wu, C. H. (2007). Adsorption of reactive dye onto carbon nanotubes: equilibrium, kinetics and thermodynamics. Journal of Hazardous Materials, 144, 93–100.
Yu, Y., Zhuang, Y. Y., & Wang, Z. H. (2001). Adsorption of water-soluble dye onto functionalized resin. Journal of Colloid and Interface Science, 242, 288–293.
Zhang, T. J. (2009). Application and development of activated carbon for portable water treatment in china. Biology Chemical Engineering, 43(6), 54–59.
Zhiyuan, W., Chao, W., Peifang, W., Jin, Q., Jun, H., & Yanhui, A. (2014). Process optimization for microcystin-LR adsorption onto nano-sized montmorillonite K10: application of response surface methodology. Water Air Soil Pollution, 225, 2124.
The authors would like to appreciate the efforts of the team of LBMPT laboratory for his encouragement throughout this project.
About this article
Cite this article
Boukhelkhal, A., Benkortbi, O., Hamadeche, M. et al. Removal of Amoxicillin Antibiotic from Aqueous Solution Using an Anionic Surfactant. Water Air Soil Pollut 226, 323 (2015). https://doi.org/10.1007/s11270-015-2587-z
- Aqueous solutions
- Sodium dodecyl sulfate
- Mass transfer