Water, Air, & Soil Pollution

, Volume 223, Issue 8, pp 5097–5104 | Cite as

Assessing the Oxidative Stress Induced by Paracetamol Spiked in Artificial Sediment on Hyalella azteca

  • Leobardo Manuel Gómez-Oliván
  • Nadia Neri-Cruz
  • Marcela Galar-Martínez
  • Patricia Vieyra-Reyes
  • Sandra García-Medina
  • Celene Razo-Estrada
  • Octavio Dublán-García
  • Alba Yadira Corral-Avitia
Article
First Online:
Received:
Accepted:

Abstract

Paracetamol is an antipyretic analgesic widely used globally. It has been recurrently found in water bodies and is known to elicit toxic effects in aquatic species; however, its potential ability to induce oxidative stress in sentinel species remains unknown The objective was to establish a methodology to evaluate the toxicity elicited on the sentinel species Hyalella azteca by paracetamol-enriched sediment using oxidative stress tests. Concentrations used in assays were determined using the previously obtained median lethal concentration (72 h LC50). The following oxidative stress biomarkers were evaluated: lipid peroxidation (LPO), protein carbonyl content (PCC) in order to determine oxidized protein content, and the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX). LPO and PCC increased significantly while SOD, CAT, and GPX decreased significantly (p < 0.05) with respect to controls. Paracetamol induces oxidative stress on H. azteca, and the set of tests employed is helpful in evaluating the toxicity of this group of pharmaceuticals on aquatic species.

Keywords

Paracetamol Artificial sediment Oxidative stress Hyalella azteca 
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Notes

Acknowledgments

This study was made possible through support from the Secretary of Research and Advanced Studies of the Autonomous University of Mexico State by means of Project 2971/2010SF.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Leobardo Manuel Gómez-Oliván
    • 1
    • 5
  • Nadia Neri-Cruz
    • 1
  • Marcela Galar-Martínez
    • 2
  • Patricia Vieyra-Reyes
    • 3
  • Sandra García-Medina
    • 2
  • Celene Razo-Estrada
    • 2
  • Octavio Dublán-García
    • 1
  • Alba Yadira Corral-Avitia
    • 4
  1. 1.Laboratorio de Toxicología Ambiental, Departamento de Farmacia, Facultad de QuímicaUniversidad Autónoma del Estado de MéxicoTolucaMexico
  2. 2.Laboratorio de Toxicología Acuática, Departamento de Farmacia, Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico CityMexico
  3. 3.Laboratorio de Neurofisiología de la Conducta, Facultad de MedicinaUniversidad Autónoma del Estado de MéxicoTolucaMexico
  4. 4.Laboratorio de Ciencias Ambientales, Instituto de Ciencias BiomédicasUniversidad Autónoma de Ciudad JuárezCiudad JuárezMexico
  5. 5.Laboratorio de Toxicología, Departamento de FarmaciaUniversidad Autónoma del Estado de MéxicoTolucaMexico

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