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Toxicological Studies of Mycotoxins Using Enzymatic and Histochemical Methods

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Abstract

Studies concerning mycotoxins involve activities of relevant potential for furthering knowledge in the fields of toxicology and environmental analysis. Using bioanalytical methods (biosensors, histochemistry), the conducted research aims at contributing to raising the awareness of local, national, and international media in relation to the safety of obtaining and processing vegetal and animal foods, by analyzing the possible effects of aflatoxins and ochratoxins, promoting animal health, food hygiene, in view of ensuring animal and human health. The study using laboratory animals (mice) while being part of one of the current national research directions, also holds international priority, by its contribution to a better understanding of several fundamental mechanisms of life at molecular level and to the characterization of certain biological processes that appear in mycotoxicosis.

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Acknowledgments

The authors would like to thank for the financial support granted by the Excellence Research Project for Young Researchers code 163, no. 5898/2006 (coordinator Transilvania University of Brasov, Romania).

The enzyme-related part of this work has been made possible by the continued support of Prof. Dr. Jean-Louis Marty, University of Perpignan Via Domitia, France, who provided the screen-printed electrodes and mutants of acetylcholinesterase produced by Protein BioSensor Company (Toulouse, France). The authors would like to acknowledge his support granted for the last 5 years.

The authors also thank Andrea Deaconescu for revising the English manuscript.

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Correspondence to Mihaela Badea.

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Badea, M., Taus, N., Potrovita, M. et al. Toxicological Studies of Mycotoxins Using Enzymatic and Histochemical Methods. Water Air Soil Pollut: Focus 9, 261–269 (2009). https://doi.org/10.1007/s11267-009-9211-4

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Keywords

  • Mycotoxicosis
  • Aflatoxins
  • Ochratoxins
  • Biosensors
  • Liver
  • Kidney