A Multiscale Approach for Assessing the Interactions of Environmental and Biological Systems in a Holistic Health Risk Assessment Framework
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Advances in computing processing power and in availability of environmental and biological data have allowed the development and application of comprehensive modeling systems that utilize a holistic, integrated, approach for assessing the interactions of environmental and biological systems across multiple scales of spatiotemporal extent and biological organization. This approach allows mechanism-based environmental health risk assessments in a person-oriented framework, which accounts for simultaneous exposures to contaminants from multiple media, routes, and pathways. The conceptual basis and example applications of the Modeling ENvironment for TOtal Risk (MENTOR), and the DOse–Response Information ANalysis system (DORIAN) are presented.
KeywordsComprehensive modeling systems DORIAN MENTOR Environmental health Risk assessments Exposures to mixtures
Support for this work has been provided primarily by the USEPA-funded Environmental Bioinformatics and Computational Toxicology Center (ebCTC) under STAR Grant No. GAD R 832721-010, and the USEPA funded Center for Exposure and Risk Modeling (CERM) under Cooperative Agreement no. CR-83162501. This work has not been reviewed by and does not represent the opinions of the funding agency. Appreciation is extended to the research team of CCL, with special thanks to Profs S. Isukapalli and S. W. Wang, as well as to A. Sasso, Y. C. Yang, and P. Shade. Thanks are also due to Prof P.J. Lioy (CERM), Prof W. Welsh (ebCTC), Dr W. Tong (USFDA-NCTR Center for Toxicoinformatics), and to the numerous USEPA and EOHSI collaborators who have contributed to this research.
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