Virus Genes

, Volume 54, Issue 4, pp 603–607 | Cite as

Characterization of a Pestivirus H isolate originating from goats

  • Hongfei Shi
  • Chaoliang Leng
  • Qian Xu
  • Hongling Shi
  • Shiyu Sun
  • Yunchao KanEmail author
  • Lunguang YaoEmail author


Natural Pestivirus H infections in cattle have been reported worldwide; however, only a few cases of Pestivirus H have been described in non-bovine ruminants such as goats. A new Pestivirus H HN1507 strain was isolated from an infected goat in 2015 and the genome sequence was determined. The full-length genome sequence was 12,556 nucleotides. Phylogenetic analysis, based on the complete genome and Npro fragments, revealed that the isolate belonged to Pestivirus H and was closely related to strains from Italy. Two unique amino acid substitutions were found in the C-terminal of the E2 protein. To the best of our knowledge, this is first report determining the complete genome of a Pestivirus H strain from goat.


Pestivirus H Goat Genome Npro E2 



This study was funded by the National Natural Science Foundation of China (Grant no. 31371381), the Scientific and Technological Project of Henan Province (Grant no. 162102110046), and the School Project of Nanyang Normal University (Grant no. 15081).

Authors’ Contributions

HS1 and QX participated in the design of the study, and drafted and revised the manuscript. CL, HS2, and SS participated in the sample sequencing and data analysis. YK and LY participated in the design of the study and drafted the manuscript. All authors read and approved the final manuscript.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest.


  1. 1.
    L. Liu, H. Xia, C. Baule, S. Belak, Arch. Virol. 154, 1111–1116 (2009)CrossRefPubMedGoogle Scholar
  2. 2.
    D.B. Smith, G. Meyers, J. Bukh, E.A. Gould, T. Monath, A. Scott Muerhoff, A. Pletnev, R. Rico-Hesse, J.T. Stapleton, P. Simmonds, P. Becher, J. Gen. Virol. 98, 2106–2112 (2017)CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    N. Decaro, R. Sciarretta, M.S. Lucente, V. Mari, F. Amorisco, M.L. Colaianni, P. Cordioli, A. Parisi, R. Lelli, C. Buonavoglia, Mol. Cell. Probes 26, 42–46 (2012)CrossRefPubMedGoogle Scholar
  4. 4.
    N. Decaro, V. Mari, P. Pinto, M.S. Lucente, R. Sciarretta, F. Cirone, M.L. Colaianni, G. Elia, H.J. Thiel, C. Buonavoglia, J. Gen. Virol. 93, 1976–1983 (2012)CrossRefPubMedGoogle Scholar
  5. 5.
    N. Decaro, V. Mari, M.S. Lucente, R. Sciarretta, A. Moreno, C. Armenise, M. Losurdo, M. Camero, E. Lorusso, P. Cordioli, C. Buonavoglia, Vet. Microbiol. 155, 165–171 (2012)CrossRefPubMedGoogle Scholar
  6. 6.
    N. Decaro, M.S. Lucente, V. Mari, F. Cirone, P. Cordioli, M. Camero, R. Sciarretta, M. Losurdo, E. Lorusso, C. Buonavoglia, Emerg. Infect. Dis. 17, 1549–1552 (2011)CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    N. Mishra, S.S. Pitale, K. Rajukumar, A. Prakash, S.P. Behera, R.K. Nema, S.C. Dubey, Acta. Virol. 56, 209–215 (2012)CrossRefPubMedGoogle Scholar
  8. 8.
    D.D. Nelson, M.J. Dark, D.S. Bradway, J.F. Ridpath, N. Call, J. Haruna, F.R. Rurangirwa, J.F. Evermann, J. Vet. Diagn. Invest. 20, 752–759 (2008)CrossRefPubMedGoogle Scholar
  9. 9.
    H. Shi, Y. Kan, L. Yao, C. Leng, Q. Tang, J. Ji, S. Sun, Transbound. Emerg. Dis. 63, 480–484 (2016)CrossRefPubMedGoogle Scholar
  10. 10.
    L. Liu, J. Kampa, S. Belak, C. Baule, Vet. Microbiol. 138, 62–68 (2009)CrossRefPubMedGoogle Scholar
  11. 11.
    K. Tamura, G. Stecher, D. Peterson, A. Filipski, S. Kumar, Mol. Biol. Evol. 30, 2725–2729 (2013)CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    N. Decaro, V. Mari, M.S. Lucente, R. Sciarretta, G. Elia, J.F. Ridpath, C. Buonavoglia, Vet. Microbiol. 167, 307–313 (2013)CrossRefPubMedGoogle Scholar
  13. 13.
    A.C.S. Mosena, S.P. Cibulski, M.N. Weber, S. Silveira, M.S. Silva, F.Q. Mayer, P.M. Roehe, C.W. Canal, Arch. Virol. 162, 3025–3034 (2017)CrossRefPubMedGoogle Scholar
  14. 14.
    L. Mao, W. Li, W. Zhang, L. Yang, J. Jiang, J. Virol. 86, 12444 (2012)CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    N. Decaro, G. Lanave, M.S. Lucente, V. Mari, K. Varello, M. Losurdo, V. Larocca, E. Bozzetta, N. Cavaliere, V. Martella, C. Buonavoglia, J. Clin. Microbiol. 52, 2946–2954 (2014)CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    P. Becher, G. Meyers, A.D. Shannon, H.J. Thiel, J. Virol. 70, 2992–2998 (1996)PubMedPubMedCentralGoogle Scholar
  17. 17.
    J.D. Neill, E.J. Dubovi, J.F. Ridpath, Vet. Microbiol. 179, 299–303 (2015)CrossRefPubMedGoogle Scholar
  18. 18.
    K. El Omari, O. Iourin, K. Harlos, J.M. Grimes, D.I. Stuart, Cell. Rep. 3, 30–35 (2013)CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    D. Paton, M. Gunn, J. Sands, F. Yapp, T. Drew, S. Vilcek, S. Edwards, Arch. Virol. 142, 929–938 (1997)CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Henan Provincial Engineering Laboratory of Insects Bio-reactorChina-UK-NYNU-RRes Joint Libratory of Insect Biology, Nanyang Normal UniversityNanyangPeople’s Republic of China
  2. 2.Liaoning Center for Animal Disease Control and PreventionShenyangPeople’s Republic of China

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