Characterization of a Pestivirus H isolate originating from goats
Natural Pestivirus H infections in cattle have been reported worldwide; however, only a few cases of Pestivirus H have been described in non-bovine ruminants such as goats. A new Pestivirus H HN1507 strain was isolated from an infected goat in 2015 and the genome sequence was determined. The full-length genome sequence was 12,556 nucleotides. Phylogenetic analysis, based on the complete genome and Npro fragments, revealed that the isolate belonged to Pestivirus H and was closely related to strains from Italy. Two unique amino acid substitutions were found in the C-terminal of the E2 protein. To the best of our knowledge, this is first report determining the complete genome of a Pestivirus H strain from goat.
KeywordsPestivirus H Goat Genome Npro E2
This study was funded by the National Natural Science Foundation of China (Grant no. 31371381), the Scientific and Technological Project of Henan Province (Grant no. 162102110046), and the School Project of Nanyang Normal University (Grant no. 15081).
HS1 and QX participated in the design of the study, and drafted and revised the manuscript. CL, HS2, and SS participated in the sample sequencing and data analysis. YK and LY participated in the design of the study and drafted the manuscript. All authors read and approved the final manuscript.
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Conflict of interest
The authors declare that they have no conflicts of interest.