Filaggrin gene polymorphism associated with Epstein–Barr virus-associated tumors in China
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Mutations of filaggrin gene (FLG) have been identified as the cause of ichthyosis vulgaris, while recently FLG mutations were found to be associated with gastric cancer. This study aimed to investigate the association of filaggrin polymorphism with Epstein–Barr virus-associated tumors in China. A total of 200 patients with three types of tumors and 117 normal control samples were genotyped at three common FLG mutation loci (rs3126085, K4671X, R501X) by using Sequenom MassARRAY technique. The χ 2 test was used to evaluate the relationship between the mutation and the three kinds of tumors. A two-sided P value of <0.05 was considered statistically significant. The results showed that two single-nucleotide polymorphism (SNP) loci (rs3126085, K4671X) were significantly associated with nasopharyngeal carcinoma in genetic model. In addition, the two SNPs K4671X and rs3126085 were related to Epstein–Barr virus (EBV)-associated gastric carcinoma (EBVaGC) and EBV-negative gastric carcinoma (EBVnGC), respectively. Furthermore, allele distributions in EBVaGC and EBVnGC were verified to be different in both SNP loci.
KeywordsFilaggrin SNP Epstein–Barr virus Nasopharyngeal carcinoma Gastric carcinoma
This research was supported by the National Natural Science Foundation of China (NSFC 81571995) and the Natural Science Foundation of Shandong Province (ZR2015HM069).
BL conceived the project and designed experiments. YY mainly conducted the experiments. WL, YZ, HX, ZZZ participated in performance of the experiments and the drafting of the manuscript. All authors read and approved the final manuscript.
Compliance with ethical standards
Conflict of interest
The authors declared that they have no competing interests.
This study was approved by the Medical Ethics Committee of the Medical College of Qingdao University.
Informed consents were received from all patients.
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