A novel Enterovirus 96 circulating in China causes hand, foot, and mouth disease
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Enterovirus 96 (EV-96) is a recently described member of the species Enterovirus C and is associated with paralysis and myelitis. In this study, using metagenomic sequencing, we identified a new enterovirus 96 strain (EV-96-SZ/GD/CHN/2014) as the sole pathogen causing hand, foot, and mouth disease (HFMD). A genomic comparison showed that EV-96-SZ/GD/CHN/2014 is most similar to the EV-96-05517 strain (85% identity), which has also been detected in Guangdong Province. This is the first time that metagenomic sequencing has been used to identify an EV-96 strain shown to be associated with HFMD.
KeywordsEnterovirus 96 Metagenomics HFMD Genome sequence Evolution
STG, YX, and XX designed the experiments; YSS, JMM, and SRZ wrote the manuscript; WF, JJ, LQL, and JDL performed the experiments; JWY, LMT, DL, and FCX contributed to the clinical diagnosis and collected the samples; NP, SS, XL, and HJ coordinated the genomic sequencing and conducted the phylogenetic analyses. All authors have read and approved the final manuscript.
This study was supported by the Guangzhou Bureau of Science and Telecommunications Fund (2014Y2-00197), the Technological Innovation Plan of Shenzhen—Technology Development Project (No. CXZZ20140904154910774), and a Grant from the Ministry of Science and Technology of the People’s Republic of China (2011DFA33220).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
All procedures involving human participants were in accordance with ethical standards.
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