Virus Genes

, Volume 48, Issue 2, pp 356–360 | Cite as

Complete nucleotide sequence of a norovirus GII.4 genotype: evidence for the spread of the newly emerged pandemic Sydney 2012 strain to China

  • Yuqi Huo
  • Ailing Cai
  • Hui Yang
  • Mingli Zhou
  • Jiaxin Yan
  • Dingxiang Liu
  • Shuo ShenEmail author


A newly emerged pandemic Sydney GII.4-like norovirus (NoV) (Jingzhou GII.4) was isolated in Jingzhou, China in April, 2013, demonstrating the rapid spread of the variant to China. The complete nucleotide sequence was compared with the prototype Sydney 2012 variant and its VP1 gene with that of Huzhou strain (isolated in January 2013 in Huzhou, China). The result demonstrates that the new variant has evolved rapidly, including mutations in the hypervariable P2 domain of the major capsid protein VP1. Our study also shows that the new Jingzhou GII.4 variant co-circulated with GII.3 and GI.2 at the same time, supporting further monitoring of the evolution of the new NoV variant in China.


Norovirus Pandemic Sydney 2012-like GII.4 Chinese variants Jingzhou2013GII.4 and Huzhou2013GII.4 Complete nucleotide sequence 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Yuqi Huo
    • 1
  • Ailing Cai
    • 2
  • Hui Yang
    • 2
  • Mingli Zhou
    • 2
  • Jiaxin Yan
    • 1
  • Dingxiang Liu
    • 3
  • Shuo Shen
    • 1
    Email author
  1. 1.Wuhan Institute of Biological Products Co., Ltd.WuhanChina
  2. 2.The Third People’s Hospital of JingzhouJingzhouChina
  3. 3.Nanyang Technological UniversitySingaporeSingapore

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