Virus Genes

, Volume 47, Issue 3, pp 556–558 | Cite as

Rosavirus: the prototype of a proposed new genus of the Picornaviridae family

  • Tung Gia Phan
  • Nguyen Phung Vo
  • Peter Simmonds
  • Erik Samayoa
  • Samia Naccache
  • Charles Y. Chiu
  • Eric Delwart
Article

Abstract

We describe a 8,724-nucleotide-long picornavirus genome encoding a single 2,470-aa polyprotein obtained from the feces of a wild mouse. Rosavirus is genetically closest to the double ORF Dicipivirus found in canine feces that is currently the only picornavirus with a second internal ribosome entry site (IRES). Of note, a section of rosavirus’ 5′UTR showed strong sequence and structural conservation with the type II IRES from the Parechovirus and Hungarovirus genera possibly reflecting exchange of genetic modules between genera. Based on genetic distance criteria rosavirus qualifies as prototype of a new genus of the Picornaviridae family.

Keywords

Picornavirus Feces Mice Genus 

References

  1. 1.
    T.G. Phan, B. Kapusinszky, C. Wang, R.K. Rose, H.L. Lipton, E.L. Delwart, PLoS Pathog. 7, e1002218 (2011)PubMedCrossRefGoogle Scholar
  2. 2.
    A. Kapoor, L. Li, J. Victoria, B. Oderinde, C. Mason, P. Pandey, S.Z. Zaidi, E. Delwart, J. Gen. Virol. 90, 2965–2972 (2009)PubMedCrossRefGoogle Scholar
  3. 3.
    A.S. Nateri, P.J. Hughes, G. Stanway, J. Virol. 74, 6269–6277 (2000)PubMedCrossRefGoogle Scholar
  4. 4.
    G. Reuter, P. Pankovics, N.J. Knowles, A. Boros, J. Virol. 86, 13295–13302 (2012)PubMedCrossRefGoogle Scholar
  5. 5.
    P. Simmonds, Recombination in the evolution of picornaviruses, in The Picornaviruses, ed. by E. Ehrenfeld, E. Domingo, R.P. Roos (ASM Press, Washington, DC, 2010), pp. 229–238CrossRefGoogle Scholar
  6. 6.
    F. Ghazi, P.J. Hughes, T. Hyypia, G. Stanway, J. Gen. Virol. 79(Pt 11), 2641–2650 (1998)PubMedGoogle Scholar
  7. 7.
    M. Kozak, Nucleic Acids Res. 15, 8125–8148 (1987)PubMedCrossRefGoogle Scholar
  8. 8.
    P.C. Woo, S.K. Lau, G.K. Choi, Y. Huang, J.L. Teng, H.W. Tsoi, H. Tse, M.L. Yeung, K.H. Chan, D.Y. Jin, K.Y. Yuen, J. Virol. 86, 2797–2808 (2012)PubMedCrossRefGoogle Scholar
  9. 9.
    M. Chow, J.F. Newman, D. Filman, J.M. Hogle, D.J. Rowlands, F. Brown, Nature 327, 482–486 (1987)PubMedCrossRefGoogle Scholar
  10. 10.
    N. Blom, J. Hansen, D. Blaas, S. Brunak, Protein Sci. 5, 2203–2216 (1996)PubMedCrossRefGoogle Scholar
  11. 11.
    P.J. Hughes, G. Stanway, J. Gen. Virol. 81, 201–207 (2000)PubMedGoogle Scholar
  12. 12.
    N.J. Knowles, T. Hovi, T. Hyypiä, A.M.Q. King, A.M. Lindberg, M.A. Pallansch, A.C. Palmenberg, P. Simmonds, T. Skern, G. Stanway, T. Yamashita, R. Zell, Picornaviridae, in Virus Taxonomy: Classification and Nomenclature of Viruses: Ninth Report of the International Committee on Taxonomy of Viruses, ed. by A.M.Q. King, M.J. Adams, E.B. Carstens, E.J. Lefkowitz (Elsevier, San Diego, 2012), pp. 855–880Google Scholar
  13. 13.
    C. Lauber, A.E. Gorbalenya, J. Virol. 86, 3905–3915 (2012)PubMedCrossRefGoogle Scholar
  14. 14.
    C. Lauber, A.E. Gorbalenya, J. Virol. 86, 3890–3904 (2012)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Tung Gia Phan
    • 1
    • 2
  • Nguyen Phung Vo
    • 1
    • 3
  • Peter Simmonds
    • 4
  • Erik Samayoa
    • 2
  • Samia Naccache
    • 2
  • Charles Y. Chiu
    • 2
  • Eric Delwart
    • 1
    • 2
  1. 1.Blood Systems Research InstituteSan FranciscoUSA
  2. 2.Department of Laboratory MedicineUniversity of California at San FranciscoSan FranciscoUSA
  3. 3.Pharmacology Department, School of PharmacyHo Chi Minh City University of Medicine and PharmacyHo Chi Minh CityVietnam
  4. 4.Roslin InstituteUniversity of EdinburghEdinburghUK

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