Rosavirus: the prototype of a proposed new genus of the Picornaviridae family
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We describe a 8,724-nucleotide-long picornavirus genome encoding a single 2,470-aa polyprotein obtained from the feces of a wild mouse. Rosavirus is genetically closest to the double ORF Dicipivirus found in canine feces that is currently the only picornavirus with a second internal ribosome entry site (IRES). Of note, a section of rosavirus’ 5′UTR showed strong sequence and structural conservation with the type II IRES from the Parechovirus and Hungarovirus genera possibly reflecting exchange of genetic modules between genera. Based on genetic distance criteria rosavirus qualifies as prototype of a new genus of the Picornaviridae family.
KeywordsPicornavirus Feces Mice Genus
We acknowledge NHLBI R01HL105770 and support from BSRI to E.D. We also thank staff at the Division of Communicable Disease Control, California Department of Public Health for sample collection.
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