Rosavirus: the prototype of a proposed new genus of the Picornaviridae family
We describe a 8,724-nucleotide-long picornavirus genome encoding a single 2,470-aa polyprotein obtained from the feces of a wild mouse. Rosavirus is genetically closest to the double ORF Dicipivirus found in canine feces that is currently the only picornavirus with a second internal ribosome entry site (IRES). Of note, a section of rosavirus’ 5′UTR showed strong sequence and structural conservation with the type II IRES from the Parechovirus and Hungarovirus genera possibly reflecting exchange of genetic modules between genera. Based on genetic distance criteria rosavirus qualifies as prototype of a new genus of the Picornaviridae family.
KeywordsPicornavirus Feces Mice Genus
- 12.N.J. Knowles, T. Hovi, T. Hyypiä, A.M.Q. King, A.M. Lindberg, M.A. Pallansch, A.C. Palmenberg, P. Simmonds, T. Skern, G. Stanway, T. Yamashita, R. Zell, Picornaviridae, in Virus Taxonomy: Classification and Nomenclature of Viruses: Ninth Report of the International Committee on Taxonomy of Viruses, ed. by A.M.Q. King, M.J. Adams, E.B. Carstens, E.J. Lefkowitz (Elsevier, San Diego, 2012), pp. 855–880Google Scholar