Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Characterization of a bovine viral diarrhea virus originated from cattle in Gansu Province, China


A bovine viral diarrhea disease virus (BVDV) GS-4 was isolated in Western China form dairy cattle with respiratory disease. Genomic comparison analysis with the 5′ half genome sequence encompassing the coding region of Npro, capsid, and envelope glycoproteins showed that the GS-4 should be classified into BVDV-1b1, which is considered as one of the predominant subgenotypes found in China. This classification was confirmed by phylogenetic analysis based on E2 coding region.

This is a preview of subscription content, log in to check access.

Fig. 1


  1. 1.

    P. Simmonds, P. Becher, M.S. Collett, E.A. Gould, F.X. Heinz, G. Meyers, T. Monath, A. Pletnev, C.M. Rice, K. Stiasny, H-J. Thiel, A. Weiner, J. Bukh, in Virus Taxonomy. Ninth Report of the International Committee on Taxonomy of Viruses, ed. by A.M.Q. King, M.J. Adams, E.B. Carstens, E.J. Lefkowitz (Elsevier, Academic Press. Amsterdam, Boston, Heidelberg etc., 2012), p. 1003

  2. 2.

    L. Liu, H. Xia, N. Wahlberg, S. Belák, C. Baule, Virology 385, 351–357 (2009)

  3. 3.

    T.R. Ames, in Bovine Viral Diarrhea Virus: Diagnosis, Management, and Control, ed. by J.F. Ridpath, S.M.Goyal (Blackwell Publishing Ltd, Oxford, 2005), p. 171

  4. 4.

    Y. Li, Z. Liu, Chin. J. Vet. Sci. 3, 113–120 (1983). in Chinese

  5. 5.

    H.M. Zhang, M.X. Zhang, S.P. Gu, H.L. Ma, D. Wang, Y.T. Li, Z.W. Xu, J.M. Zhang, Z.H. Wang, E.F. Wang, China Anim. Husb. Vet. Med. 36, 120–122 (2009). in Chinese

  6. 6.

    F. Zhong, N. Li, X. Huang, Y. Guo, H. Chen, X. Wang, C. Shi, X. Zhang, Virus Genes 42, 204–207 (2011)

  7. 7.

    S. Vilcek, P.F. Nettleton, D.J. Paton, S. Belak, J. Gen. Virol. 78, 725–735 (1997)

  8. 8.

    M. Tajima, H.R. Frey, O. Yamato, Y. Maede, V. Moennig, H. Scholz, I. Greiser-Wilke, Virus Res. 76, 31–42 (2001)

Download references


This study was financially supported by the National Major Special Project on New Varieties Cultivation for Transgenic Organisms (2013ZX08011004-006), NBCITS, and MOA (CARS-38).

Author information

Correspondence to Huiyun Chang or Hong Yin.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gao, S., Shao, J., Du, J. et al. Characterization of a bovine viral diarrhea virus originated from cattle in Gansu Province, China. Virus Genes 47, 178–180 (2013).

Download citation


  • BVDV-1
  • Subgenotype
  • Phylogeny
  • China