Virus Genes

, Volume 41, Issue 1, pp 1–4

Genetic analysis of the VP1 region of enterovirus 71 reveals the emergence of genotype A in central China in 2008

  • Haiyang Yu
  • Wei Chen
  • Hongwei Chang
  • Renshu Tang
  • Jun Zhao
  • Lin Gan
  • Boyu Liu
  • Jason Chen
  • Mingli Wang
Article
  • 301 Downloads

Abstract

Enterovirus 71 (EV71) strains from children were characterized by full-length VP1 nucleotide sequencing. Out of 22 clinical specimens, five isolates identified as EV71 were recovered by virus isolation. The VP1 sequences of the five isolates had more than 97.4% sequence identity with prototype virus BrCr, clustering in the genotype A lineage. This represents the first record of genotype A EV71 in China since the BrCr prototype strain was discovered in the USA in 1969.

Keywords

Hand, foot, and mouth disease Enterovirus 71 VP1 gene Genotype A Phylogenetic analysis 

Abbreviations

EV

Enterovirus

HFMD

Hand, foot, and mouth disease

CA16

Coxsackievirus A16

RT-PCR

Reverse transcription-polymerase chain reaction

CSF

Cerebrospinal fluid

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Haiyang Yu
    • 1
    • 2
  • Wei Chen
    • 1
    • 2
  • Hongwei Chang
    • 1
    • 3
  • Renshu Tang
    • 1
    • 2
  • Jun Zhao
    • 1
    • 2
  • Lin Gan
    • 1
    • 2
  • Boyu Liu
    • 1
    • 2
  • Jason Chen
    • 1
    • 4
  • Mingli Wang
    • 1
    • 2
  1. 1.Department of MicrobiologyAnhui Medical UniversityHefeiChina
  2. 2.Key Laboratory of Gene Resource Utilization for Severe DiseasesThe Ministry of Education of China and Anhui ProvinceHefeiChina
  3. 3.Lu’an Center for Disease Control and PreventionLu’anChina
  4. 4.Department of Pathology and Cell BiologyColumbia UniversityNew YorkUSA

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