Virus Genes

, 39:293

Molecular evolution of novel swine-origin A/H1N1 influenza viruses among and before human

  • Na Ding
  • Nana Wu
  • Qinggang Xu
  • Keping Chen
  • Chiyu Zhang
Article

DOI: 10.1007/s11262-009-0393-7

Cite this article as:
Ding, N., Wu, N., Xu, Q. et al. Virus Genes (2009) 39: 293. doi:10.1007/s11262-009-0393-7

Abstract

We find that the novel A/H1N1 influenza viruses exhibit very low genetic divergence and suffer strong purifying selection among human population and confirm that they originated from the reassortment of previous triple-reassortant swine influenza viruses including genomic segments from both avian and human lineages with North American and Eurasian swine lineages. The longer phylogenetic branch length to their nearest genetic neighbors indicates that the origin of the novel A/H1N1 is unlikely to be a very recent event. Seventy-six new unique mutations are found to be monomorphically fixed in the novel A/H1N1 virus lineages, suggesting a role of selective sweep in the early evolution of this virus.

Keywords

Novel A/H1N1 influenza virus Reassortment Adaptive evolution Selective sweep 

Supplementary material

11262_2009_393_MOESM1_ESM.doc (74 kb)
Supplementary material 1 (DOC 73 kb)
11262_2009_393_MOESM2_ESM.pdf (72 kb)
Supplementary material 2 (PDF 71 kb)

Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Na Ding
    • 1
  • Nana Wu
    • 1
  • Qinggang Xu
    • 1
  • Keping Chen
    • 1
  • Chiyu Zhang
    • 1
  1. 1.Institute of Life SciencesJiangsu UniversityZhenjiangChina

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