Virus Genes

, 37:282 | Cite as

New variants of human papillomavirus type 18 identified in central Brazil

  • Daniela Marreco Cerqueira
  • Tainá Raiol
  • Nazle Mendonça Collaço Véras
  • Natália von Gal Milanezi
  • Fádia Aguiar Amaral
  • Marcelo de Macedo Brígido
  • Cláudia Renata Fernandes Martins
Article

Abstract

HPV-18 is the second most prevalent human papillomavirus genotype found in cervical cancer. Nucleotide variations in HPV-18 sequence can interfere with the viral oncogenic potential. However, the knowledge about HPV-18 variants in Brazil is still limited. The present study aims to determine the LCR, E6, and L1 genetic variability of HPV-18 variants found in women co-infected with HIV-1 in Central Brazil. Four HPV-18 samples were identified and had the LCR, E6, and L1 genomic regions sequenced. It was possible to characterize three European variants and one African variant of HPV-18. All of them are new variants, showing nucleotide substitutions not previously reported. Nucleotide variations in binding sites for transcriptional factors were observed. Phylogenetic analysis was also performed, evidencing the three clusters related to the Asian-American, African, and European variants. The characterization of HPV genetic variability is of pivotal importance to the understanding of the viral pathogenicity.

Keywords

HPV-18 Brazil HPV variants HIV-1 

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Daniela Marreco Cerqueira
    • 1
    • 2
  • Tainá Raiol
    • 1
  • Nazle Mendonça Collaço Véras
    • 1
  • Natália von Gal Milanezi
    • 1
  • Fádia Aguiar Amaral
    • 3
  • Marcelo de Macedo Brígido
    • 1
  • Cláudia Renata Fernandes Martins
    • 1
  1. 1.Pós-Graduação em Biologia MolecularInstituto de Biologia, Universidade de Brasília ICC SulBrasíliaBrazil
  2. 2.ANVISA, Ministry of HealthBrasíliaBrazil
  3. 3.Unidade Mista de Saúde da Asa SulBrasíliaBrazil

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