Long RNA electropherotype rotavirus strains with subgroup I specificity predominated the infantile gastroenteritis outbreak in Manipur, India, in 1987–88. One such strain (RMC321) was found to possess porcine characteristics in 7 out of 8 genes sequenced. Partial characterization of its remaining VP1, VP2 and VP3 genes along with a porcine rotavirus strain (HP140) uncovered their close genetic relation to porcine strains. VP7 was the only gene segment of this strain with significant genetic identity to human strains. This indicates that a rotavirus reassortant strain with most of its genetic material derived from a porcine strain may cause symptomatic infection in a human host.
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The research was funded by Indian Council of Medical Research (ICMR), New Delhi, India. V. Varghese, S. Ghosh and S. Das were supported by Senior Research Fellowships from Indian Council of Medical Research and Council of Scientific and Industrial Research, New Delhi, India.
The nucleotide sequence data reported in this paper have been submitted to the GenBank nucleotide sequence database and have been assigned accession numbers AY601114 and AY601117 for VP1, AY601115 and AY601118 for VP2 gene and AY601116 and AY601119 for VP3 gene of RMC321 and HP140 respectively.
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Varghese, V., Ghosh, S., Das, S. et al. Characterization of VP1, VP2 and VP3 Gene Segments of A Human Rotavirus Closely Related to Porcine Strains. Virus Genes 32, 241–247 (2006). https://doi.org/10.1007/s11262-005-6908-y
- Human rotavirus
- Gene segment
- Molecular characterization
- Porcine strain