Virus Genes

, Volume 30, Issue 3, pp 341–347

Genetic Characterization of Rabies Virus Isolates in Korea



In investigation of the genetic characteristics of rabies viruses in Korea, the nucleotide and deduced amino acid sequences of the nucleoprotein (N) gene were determined in four Korean rabies virus strains obtained from dogs and raccoons, and were compared with published sequences for non-Korean rabies viruses. Three Korean rabies virus isolates had identical nucleotide sequences, and the fourth differed at only one nucleotide position. The Korean virus isolates had 84.5–92.0% nucleotide sequence similarity and 94.0–99.2% amino acid sequence similarity with non-Korean rabies virus isolates. In a phylogenetic tree based on partial nucleotide sequences of the N gene, the Korean rabies viruses formed a single cluster closely related to Arctic rabies viruses (FXCAN, 9141RUS, and 94260NEP). However, they were divergent from other Asian rabies viruses (94256SRL, 8677MAL, ChiNo.7, Phil 12301, and Mdn1278).


nucleoprotein gene rabies virus sequence 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    World Health Organization, Rabies. Fact Sheet No99, 2001Google Scholar
  2. 2.
    Murphy, F.A.Fauquet, C.M.Bishop, D.H.L.Ghabrial, S.A.Jarvis, A.W.Martelli, G.P.Mayo, M.A.and Summers, M.D. eds. 1995Virus TaxonomySpringer-VerlagWien, New York275288Google Scholar
  3. 3.
    Knipe, D.M.Howley, P.M.Griffin, D.E.Lamb, R.A.Martin, M.A.Roizman, B.and Straus, S.E. eds. 2001Field VirologyLippincott Williams & WilkinsPhiladelphia12211277Google Scholar
  4. 4.
    Bourthy, K., Kissi, B., Tordo, N. 1993Virology1947081Google Scholar
  5. 5.
    Wiktor, T.J., Clark, H.F. 1973Ann Microbiol124A283287Google Scholar
  6. 6.
    Ertl, H.C., Dietzschold, B., Gore, M., Otvos, L.,Jr, Larson, J.K., Wunner, W.H., Koprowski, H. 1989J Virol6328852892Google Scholar
  7. 7.
    Hooper, D.C., Pierard, I., Modelska, A., Otvos, L.,Jr, Fu, Z.F., Koprowski, H., Dietzschold, B. 1994Proc Natl Acad Sci USA911090810912Google Scholar
  8. 8.
    Kissi, B., Tordo, N., Bourhy, H. 1995Virology209526537Google Scholar
  9. 9.
    Arai, Y.T., Yamada, K., Kameoka, Y., Horimoto, T., Yamamoto, K., Yabe, S., Nakayama, M., Tashiro, M. 1997Arch Virol14217871796Google Scholar
  10. 10.
    Nishizono, A., Mannen, K., Elio-Villa, L.P., Tanaka, S., Li, K.S., Mifune, K., Arca, B.F., Cabanban, A., Martinez, B., Rodriguez, A., Atienza, V.C., Camba, R., Resontoc, N. 2002Microbiol Immunol46413417Google Scholar
  11. 11.
    Johnson, N., McElhinney, L.M., Smith, J., Lowings, P., Fooks, A.R. 2002Arch Virol14721112123Google Scholar
  12. 12.
    Hyung, S.-H., Won, B.-R., Lee, K.-M. 1962Korean J Vet Res213Google Scholar
  13. 13.
    Jun, M.H., Kim, Y.H. 1983Kor J Vet Publ Hlth7129132Google Scholar
  14. 14.
    Kim, J.-H., Hwang, E.-K., Mo, I.-P., Yoon, Y.-D., Sin, M.-K., Kim, J.-S. 1994RDA J Agric Sci36562569Google Scholar
  15. 15.
    Nadin-Davis, S.A., Casey, G.A., Wandeler, A. 1993J Gen Virol74829837Google Scholar
  16. 16.
    Sacramento, D., Badrane, H., Bourhy, H., Tordo, N. 1992J Gen Virol7311491158Google Scholar
  17. 17.
    Ito, N., Sugiyama, M., Oraveerakul, K., Piyaviriyakul, P., Lumlertdacha, B., Arai, Y.T., Tamura, Y., Mori, Y., Minamoto, N. 1999Microbiol Immunol43551559Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2005

Authors and Affiliations

  • Yoo Jin Park
    • 1
  • Myung Kyun Shin
    • 2
  • Hyuk Moo Kwon
    • 1
  1. 1.Laboratory of Veterinary Microbiology, Department of Veterinary MedicineKangwon National UniversityChunchonRepublic of Korea
  2. 2.Gangwon Veterinary Service LaboratoryChunchonRepublic of Korea

Personalised recommendations