Virus Genes

, Volume 33, Issue 2, pp 229–234

Characterization of a new Puumala virus genotype associated with hemorrhagic fever with renal syndrome

Original Article


Hantavirus serotype Puumala (PUUV) is the etiologic agent of Nephropathia epidemica (NE), a mild variant of Hemorrhagic Fever with Renal Syndrome (HFRS) in Europe, with lethality rates up to 1% among human patients. The serotype PUUV is composed of numerous geographically restricted strains forming a great number of phylogeographic lineages, sublineages, variants, and clusters. We describe a new, geographically and phylogenetically well-defined pathogenic PUUV sublineage in Southwest Germany (strain Heidelberg/hu) originated from an HFRS patient. The genetic analysis of PUUV strain Heidelberg/hu may contribute in future to better diagnostics, the development of vaccines, and the understanding of the factors that determine hantavirus pathogenesis.


Hantavirus Puumala Genotype Phylogenetic tree HFRS 


  1. 1.
    C.S. Schmaljohn, J.M. Dalrymple, Virology 131, 482–491 (1983)PubMedCrossRefGoogle Scholar
  2. 2.
    M.H.V. Van Regenmortel, C.M. Fauquet, D.H.L. Bishop, E.B. Carsten, M.K. Estes, S.M. Lemon, J. Maniloff, M.A. Mayo, D.J. McGeoch, C.R. Pringle, R.B. Wickner, Virus taxonomy. Seventh report of the International Committee on Taxonomy of Viruses. R.M. Elliott, M. Bouloy, C.H. Calisher, R. Goldbach, J.T. Moyer, S.T. Nichol, R. Pettersson, A. Plyusnin, C.S. Schmaljohn, Family Bunyaviridae. Academic Press, San Diego, California, USA, 599–621, (2000)Google Scholar
  3. 3.
    W. Muranyi, U. Bahr, M. Zeier, F.J. van der Woude, J. Am. Soc. Nephrol. 16, 3669 (2005)PubMedCrossRefGoogle Scholar
  4. 4.
    C.A. Tidona, G. Darai, The Springer Index of Viruses. Springer-Verlag, Berlin, Heidelberg, New York (2002)Google Scholar
  5. 5.
    M. Zeier, M. Handermann, U. Bahr, B. Rensch, S. Müller, R. Kehm, W. Muranyi, G. Darai, Virus Genes 30, 157 (2005)PubMedCrossRefGoogle Scholar
  6. 6.
    A. Plyusnin, S.P. Morzunov, Curr. Top Microbiol. Immunol. 256, 47 (2001)PubMedGoogle Scholar
  7. 7.
    T. Sironen, A. Vaheri, A. Plyusnin, J. Virol. 75, 11803 (2001)PubMedCrossRefGoogle Scholar
  8. 8.
    P. Maes, J. Clement, I. Gavrilovskaya, M. Van Ranst, Viral. Immunol. 17, 481 (2004)PubMedCrossRefGoogle Scholar
  9. 9.
    O. Vapalahti, J. Mustonen, A. Lundkvist, H. Henttonen, A. Plyusnin, A. Vaheri, Lancet Infect. Dis. 3, 653 (2003)PubMedCrossRefGoogle Scholar
  10. 10.
    A. Heiske, B. Anheier, J. Pilaski, H.D. Klenk, H.J. Grone, H. Feldmann, Kidney Int. 55, 2062 (1999)PubMedCrossRefGoogle Scholar
  11. 11.
    D. Higgins, J. Thompson, T. Gibson, J.D. Thompson, D.G. Higgins, T.J. Gibson, Nucl. Acids Res. 22, 4673 (1994)PubMedGoogle Scholar
  12. 12.
    S.F. Altschul, T.L. Madden, A.A. Schäffer, J. Zhang, Z. Zhang, W. Miller, D.J. Lipman, Nucl. Acids Res. 25, 3389 (1997)PubMedCrossRefGoogle Scholar
  13. 13.
    J. Felsenstein, Cladistics 5, 164 (1998)Google Scholar
  14. 14.
    A. Dekonenko, V. Yakimenko, A. Ivanov, V. Morozov, P. Nikitin, S. Khasanova, T. Dzagurova, E. Tkachenko, C. Schmaljohn, Infect. Genet. Evol. 3, 245 (2003)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  1. 1.Klinikum der Universität HeidelbergHeidelbergFederal Republic of Germany

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