Advertisement

Veterinary Research Communications

, Volume 33, Issue 8, pp 971–977 | Cite as

Effect of induced pyrexia on the disposition kinetics of ciprofloxacin in dogs

  • Faqir MuhammadEmail author
  • Masood Akhtar
  • M. Irfan Anwar
  • M. Javed Arshed
Original Article
  • 72 Downloads

Abstract

Ciprofloxacin was administered intravenously @ 5 mg/kg body weight to six healthy dogs. After a washout period of two weeks, fever was induced by injecting Escherichia (E) coli endotoxin. Ciprofloxacin was administered again. Blood samples were collected at various time intervals and analyzed for ciprofloxacin with HPLC. The kinetic analysis revealed the volume of distribution in healthy vs. febrile dogs as 2.12 ± 0.32 vs. 1.79 ± 0.43 L/Kg, respectively. The elimination half life was 2.23 ± 0.78 and 2.07 ± 0.74 hours in healthy and febrile dogs, respectively. Similarly, dogs under healthy and febrile conditions showed comparable total plasma clearance of 0.66 ± 0.06 and 0.60 ± 0.07 L/Kg/h, respectively. All these and other investigated kinetic parameters were statistically non significant. This study concludes that the pharmacokinetic behavior of ciprofloxacin is similar under healthy and febrile conditions. Thus, the kinetic studies of fluoroquinolones conducted in normal/healthy animals may be used to depict the pharmacokinetic parameters in diseased animals.

Keywords

Pharmacokinetics Ciprofloxacin Dogs Febrile Healthy 

References

  1. Abadia AR, Aramayona JJ, Munoz MJ et al (1994) Disposition of ciprofloxacin following intravenous administration in dogs. J. Vet. Pharmacol. Therapeut. 17(5): 384–388 doi: 10.1111/j.1365-2885.1994.tb00264.x CrossRefGoogle Scholar
  2. Abadia AR, Aramayona JJ, Munoz MJ et al (1995) Ciprofloxacin pharmacokinetics in dogs following oral administration. Zentralbl Veterinarmed A 42 (8): 505–511PubMedGoogle Scholar
  3. Ahmad M, Ahmad T, Bukhary MI (1999) Disposition kinetics of erythromycin in normally and experimentally induced febrile rabbits Eur J Drug Metab Pharmacok 24: 127–132Google Scholar
  4. Ali BH (1997) The hepatic and duodenal activities of some drug metabolizing enzymes in chickens: Influence of infection with E. coli endotoxin and coccidiosis. Eur J Drug Metab Pharmacok 22: 223–227CrossRefGoogle Scholar
  5. Alovero FL, Pan XS, Morris JE et al (2000) Engineering the specificity of antibacterial fluoroquinolones: benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase. Antimicrob Agents Chemother 44: 320–325 doi: 10.1128/AAC.44.2.320-325.2000 CrossRefPubMedGoogle Scholar
  6. Bidgood TL, Papich MG (2005) Plasma and interstitial fluid pharmacokinetics of enrofloxacin, its metabolite ciprofloxacin, and marbofloxacin after oral administration and a constant rate intravenous infusion in dogs. J Vet Pharmacol. Therapeut 28 (4): 329–41CrossRefGoogle Scholar
  7. Boothe DM, Boeckh A, Boothe HW et al (2002) Plasma concentrations of enrofloxacin and its active metabolite ciprofloxacin in dogs following single oral administration of enrofloxacin at 7.5, 10, or 20 mg/kg. Vet Therap 3(4): 409-419Google Scholar
  8. Chocarro A, Gonzalez A, Garcia I (2000) Treatment of tularemia with ciprofloxacin. Clin Infect Dis 31: 623. doi: 10.1086/313946 CrossRefPubMedGoogle Scholar
  9. Drlica K, Zhao X (1997) DNA gyrase, topoisomearase IV, and the 4-quinolones. Microb Mol Biol Rev 61: 377–392Google Scholar
  10. Hasegawa T, Takagi K, Kitaichi K (1999) Effects of bacterial endotoxin on drugs pharmacokinetics. Nagoya J Med Sci 62: 11–18PubMedGoogle Scholar
  11. Hooper DC (2000) Quinolones. In: Mandell GL, Bennett JE, Dolin R (ed) Principles and Practice of Infectious Diseases, 5th edn. Churchill Livingstone, New York, U.S.A, pp. 404–423Google Scholar
  12. Hooper DC, Wolfson JS (1991) Fluoroquinolone antimicrobial agents. New England J Med 324: 384–394Google Scholar
  13. Jernigan AD, Hatch RC, Wilson RC et al (1988) Pathologic changes and tissue gentamicin concentrations after intravenous gentamicin administration in clinically normal and endotoxemic cats. Am J Vet Res 49: 613–617PubMedGoogle Scholar
  14. Jha K, Roy BK, Singh RC (1996) The effect of induced fever on the biokinetics of Norfloxacin and its interaction with probenecid in goats. Vet Res Commun 20(5): 473–479 doi: 10.1007/BF00419185 CrossRefPubMedGoogle Scholar
  15. Nawaz M, Iqbal T, Nawaz R (1988) Geonetical considerations in disposition kinetic and evaluation of chemotherapeutic agents. Veterinary Pharmacology Toxicology and therapy in food producing animals, Vol 2, p 260. Congress of European Association of Pharmacology and Therapeutics, August 28–September 2, Budapest.Google Scholar
  16. Rao GS, Ramesh S, Ahmad AH et al (2000) Effects of endotoxin-induced fever and probenecid on disposition of enrofloxacin and its metabolite ciprofloxacin after intravascular administration of enrofloxacin in goats J Vet Pharmacol Therapeut 23(6): 365–372CrossRefGoogle Scholar
  17. Rao GS, Ramesh S, Ahmad AH et al (2001) Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intramuscular administration of enrofloxacin in goats. Vet Res Commun 25(3): 197–204 doi: 10.1023/A:1006481625615 CrossRefPubMedGoogle Scholar
  18. Salam Abdullah A, Baggot JD (1986) Influence of induced disease states on the disposition kinetics of imidocarb in goats. J Vet Pharmacol Therapeut 9: 192-197 doi: 10.1111/j.1365-2885.1986.tb00029.x CrossRefGoogle Scholar
  19. Van Miert ASJPAM (1990) Influence of febrile disease on the pharmacokinetics of veterinary drugs. Annal de Recher Vet 21(Suppl. 1): 11S–28S.Google Scholar
  20. Vancutsem PM, Babish JG, Schwark WS (1990) The fluoroquinolone antimicrobials: structure, antimicrobial activity, pharmacokinetics, clinical use in domestic animals and toxicity. Cornell Vet 80: 173–186PubMedGoogle Scholar
  21. Waxman S, San Andres MD, Gonzalez F et al (2003) Influence of Escherichia coli endotoxin-induced fever on the pharmacokinetic behaviour of marbofloxacin after intravenous administration in goats. J Vet Pharmacol Therapeut 26: 65–69 doi: 10.1046/j.1365-2885.2003.00462.x CrossRefGoogle Scholar
  22. Wentland M, Heifetz CL, Domagala JM (1990) Structure activity relationships of floroquinolones. In: Siporins (ed) The New Generation of Quinolones, Marcel Dekker, New York U.S.A. pp.01–43Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Faqir Muhammad
    • 1
    Email author
  • Masood Akhtar
    • 2
  • M. Irfan Anwar
    • 3
  • M. Javed Arshed
    • 4
  1. 1.Department of Physiology and PharmacologyUniversity of Agriculture FaisalabadIslamabadPakistan
  2. 2.Department of ParasitologyUniversity of Agriculture FaisalabadIslamabadPakistan
  3. 3.Livestock and Dairy Development DepartmentGovt. of the PunjabPakistan
  4. 4.National Veterinary LaboratoryIslamabadPakistan

Personalised recommendations