The immunmodulatory effects of dl-α tocopherol (vitamin E) and levamisole on the immune system and some blood parameters of newborn Jersey calves were investigated with the present study. Treatment groups 1, 2 and 3 were injected 13,3 ml isotonic saline solution (0,9% NaCl), 3 mg/kg levamisole HCl and 2000 IU vitamin E weekly, starting at birth until the age of two weeks. Average serum IgM levels of the control, levamisole and vitamin E calves were 111,7 ± 9,3 mg/100 ml, 251,9 ± 27,6 mg/100 ml, 202,2 ± 43,3 mg/100 ml respectively on day 22. Average serum IgG levels of the levamisole and vitamin E groups elevated, compared to the control group on days 1, 8, 15 and 22. However, there were stastistically differences in treatment and control groups for serum total cholesterol, low density lipoprotein (LDL), high density lipoprotein (HDL), triglyceride and cortisol values and whole blood counts. All differences were in the reference ranges. Levamisole and vitamin E could be used as an alternative way for their beneficial effects such as improving the humoral immune responses of calves and their safety and practical use against the neonatal period infections in the field.
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This study was undertaken in The Directorship of Samsun Karaköy Agricultural Enterprises with the grate permission of the Chief Dr. Ahmet Cıra. The authors appreciate the valuable help of Filiz Akdag for statistical analysis of the data and Ertan Emek Onuk for the ELISA analysis of the samples and our Department chief Yucel Meral for his general support. The authors also wish to thank to Gokmen Zafer Pekmezci and Guvenc Gokalp for their technical assistance and Adem Usta for his general support. We are also grateful to the staff of The Directorship of Samsun Karaköy Agricultural Enterprises for the care and handling of calves.
Conflicts of interest
The authors declare that there are no conflicts of interest.
This manuscript was preapared from the PhD. Dissertation of Didem Pekmezci.
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Pekmezci, D., Cakiroglu, D. Investigation of Immunmodulatory effects of levamisole and vitamin E on Immunity and some blood parameters in newborn Jersey calves. Vet Res Commun 33, 711–721 (2009). https://doi.org/10.1007/s11259-009-9220-9
- Vitamin E
- Jersey calf