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Altered pharmacokinetics of enrofloxacin in experimental models of hepatic and renal impairment

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Abstract

We investigated the effects of hepatic and renal impairment on the pharmacokinetics of enrofloxacin in Sprague-Dawley rats. Experimental hepatic and renal failure were induced by carbon tetrachloride (CCL4) and 5/6 nephrectomy, respectively. After intravenous dosing of enrofloxacin (10 mg/kg), plasma concentrations of enrofloxacin were measured using liquid chromatograph/mass spectrometry. There was no significant effect of hepatic impairment on enrofloxacin pharmacokinetics. However, renal impairment markedly prolonged elimination half life (t1/2λz) of enrofloxacin (P < 0.05), comparing with respective control. Total body clearance (Clb) and volume of distribution at steady state (Vss) were significantly decreased (P < 0.05) by renal impairment. In conclusion, these results suggested that renal impairment could affect the pharmacokinetics of enrofloxacin.

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Correspondence to H. I. Yun.

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Hwang, Y.H., Kim, M.S., Song, I.B. et al. Altered pharmacokinetics of enrofloxacin in experimental models of hepatic and renal impairment. Vet Res Commun 33, 481–487 (2009). https://doi.org/10.1007/s11259-008-9195-y

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Keywords

  • Enrofloxacin
  • Pharmacokinetics
  • Renal impairment
  • Hepatic impairment
  • Rats