Veterinary Research Communications

, Volume 32, Issue 3, pp 225–230

Aggressive dogs are characterized by low omega-3 polyunsaturated fatty acid status

Original Article

Abstract

Canine aggressive behaviour is one of the most common problems being reported by dog owners. However, the biochemical basis of this phenomenon remains unclear. In humans, alterations in omega-3 plasma polyunsatured fatty acids and elevated omega6/omega-3 ratio have been linked to behavioural alterations, including aggression. Thus far, however, the relationship between plasma polyunsatured fatty acid status and aggression has not been investigated in the dog. In the present study we sought to investigate whether polyunsatured fatty acid status could be altered in plasma of pathologically aggressive Canis familiaris. Eighteen adult male German Shepherd dogs, aged 4.9 ± 0.9 years, showing no clinical signs but aggression, were investigated. Eighteen healthy male dogs, aged 4.8 ± 0.7 years, with a negative history of behavioural and neurological disorders served as controls. Baseline fasting plasma polyunsatured fatty acid composition was determined by gas chromatography. Compared to normal dogs, aggressive dogs showed lower docosahexaenoic acid (22:6 n-3) concentrations and a higher omega6/omega-3 ratio. In addition, they showed reduced cholesterol and bilirubin concentrations compared to their normally behaving counterparts. Altogether, our results suggest that low omega-3 fatty acids may adversely impact behaviour in dogs, resulting in greater propensity to aggression. However, given the cross-sectional design of our study, we cannot claim any causal relationship between the presence of alterations in fatty acid status and canine aggressiveness. Whether omega-3 fatty acids supplementation may be useful to reduce aggressive behaviour in the dog deserves further investigation.

Keywords

Aggression Behaviour Cholesterol Dog Fatty acids 

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References

  1. Buydens-Branchey, L., Branchey, M., McMakin, D.L. and Hibbeln, J.R., 2003. Polyunsaturated fatty acid status and aggression in cocaine addicts. Drug and Alcohol Dependence, 71, 319–323PubMedCrossRefGoogle Scholar
  2. DeMar, J.C., Ma, K., Bell, J.M., Igarashi, M., Greenstein, D. and Rapoport, S.I., 2006. One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats. Journal of Lipid Research, 47, 172–180PubMedCrossRefGoogle Scholar
  3. Golomb, B.A., 1998. Cholesterol and violence: is there a connection? Annals of Internal Medicine, 128, 478–487PubMedGoogle Scholar
  4. Golomb, B.A., Stattin, H. and Mednick, S., 2000. Low cholesterol and violent crime. Journal of Psychiatric Research, 34, 301–309PubMedCrossRefGoogle Scholar
  5. Hall, J.A., Picton, R.A., Skinner, M.M., Jewell, D.E. and Wander, R.C., 2006. The (n-3) fatty acid dose, independent of the (n-6) to (n-3) fatty acid ratio, affects the plasma fatty acid profile of normal dogs. Journal of Nutrition, 136, 2338–2344PubMedGoogle Scholar
  6. Hallahan, B. and Garland, M.R., 2004. Essential fatty acids and their role in the treatment of impulsivity disorders. Prostaglandins, Leukotrienes and Essential Fatty Acids, 71, 211–216CrossRefGoogle Scholar
  7. Hallahan, B., Hibbeln, J.R., Davis, J.M. and Garland, M.R., 2007. Omega-3 fatty acid supplementation in patients with recurrent self-harm. Single-centre double-blind randomised controlled trial. British Journal of Psychiatry, 190, 118–122PubMedCrossRefGoogle Scholar
  8. Hibbeln, J.R., Umhau, J.C., George, D.T. and Salem, N. Jr., 1997. Do plasma polyunsaturates predict hostility and depression? World Review of Nutrition & Dietetics, 82, 175–186CrossRefGoogle Scholar
  9. Hibbeln, J.R., Ferguson, T.A. and Blasbalg, T.L., 2006. Omega-3 fatty acid deficiencies in neurodevelopment, aggression and autonomic dysregulation: opportunities for intervention. International Review of Psychiatry, 18, 107–118PubMedCrossRefGoogle Scholar
  10. Kaplan, J.R., Manuck, S.B. and Shively, C., 1991. The effects of fat and cholesterol on social behavior in monkeys. Psychosomatic Medicine, 53, 634–642PubMedGoogle Scholar
  11. Kaplan, J.R., Shively, C.A., Fontenot, M.B., Morgan, T.M., Howell, S.M., Manuck, S.B., Muldoon, M.F. and Mann, J.J., 1994. Demonstration of an association among dietary cholesterol, central serotonergic activity, and social behavior in monkeys. Psychosomatic Medicine, 56, 479–484PubMedGoogle Scholar
  12. Kitamura, Y., Ishida, Y., Takata, K., Mizutani, H., Kakimura, J., Inden, M., Nakata, J., Taniguchi, T., Tsukahara, T., Akaike, A. and Shimohama, S., 2003. Hyperbilirubinemia protects against focal ischemia in rats. Journal of Neuroscience Research, 71, 544–550PubMedCrossRefGoogle Scholar
  13. Mikkelsen, J. and Lund, J.D., 2000. Euthanasia of dogs due to behavioural problems: an epidemiological study of euthanasia of dogs in Denmark, with a special focus on problems of aggression. European Journal of Companion Animal Practice, 10, 143–150Google Scholar
  14. Olsson, N.U., Shoaf, S.E. and Salem, N. Jr., 1998. The effect of dietary polyunsatured fatty acids and alcohol on neutrasmitters levels in rat brain. Nutritional Neuroscience, 1, 133–140Google Scholar
  15. Sentürk, S. and Yalçin, E., 2003. Hypocholesterolaemia in dogs with dominance aggression. Journal of Veterinary Medicine Series A. Physiology, Pathology, Clinical Medicine, 50, 339–342CrossRefGoogle Scholar
  16. Song, J. and Wander, R.C., 1991. Effects of dietary selenium and fish oil (MaxEPA) on arachidonic acid metabolism and hemostatic function in rats. Journal of Nutrition, 121, 284–292PubMedGoogle Scholar
  17. Sublette, M.E., Hibbeln, J.R., Galfalvy, H., Oquendo, M.A. and Mann, J.J., 2006. Omega-3 polyunsaturated essential fatty acid status as a predictor of future suicide risk. American Journal of Psychiatry, 163, 1100–1102PubMedCrossRefGoogle Scholar
  18. Vancassel, S., Blondeau, C., Lallemand, S., Cador, M., Linard, A., Lavialle, M. and Dellu-Hagedorn, F., 2007. Hyperactivity in the rat is associated with spontaneous low level of n-3 polyunsaturated fatty acids in the frontal cortex. Behavioural Brain Research, 180, 119–126PubMedCrossRefGoogle Scholar
  19. van den Berg, L., Kwant, L., Hestand, M.S., van Oost, B.A. and Leegwater, P.A., 2005. Structure and variation of three canine genes involved in serotonin binding and transport: the serotonin receptor 1A gene (htr1A), serotonin receptor 2A gene (htr2A), and serotonin transporter gene (slc6A4). Journal of Heredity, 96, 786–796PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  1. 1.Department of Animal BiologyUniversity of PaviaPaviaItaly
  2. 2.Santa Lucia Veterinary ClinicsTortonaItaly
  3. 3.Interdepartmental Center for Research in Molecular MedicineUniversity of PaviaPaviaItaly

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