Veterinary Research Communications

, Volume 31, Supplement 1, pp 85–90 | Cite as

Tick Vaccines and the Transmission of Tick-Borne Pathogens

  • J. de la FuenteEmail author
  • K. M. Kocan
  • E. F. Blouin

de la Fuente, J., Kocan, K.M. and Blouin, E.F., 2007. Tick vaccines and the transmission of tick-borne pathogens. Veterinary Research Communications, 31(Suppl. 1), 85–90


4D8 64P Koch’s postulates RNA interference subolesin TROSPA 


Ticks transmit pathogens that cause diseases which greatly impact both human and animal health. Vaccines developed against Boophilus spp. using Bm86 and Bm95 tick gut antigens demonstrated the feasibility of using vaccines for control of tick infestations. These vaccines also reduced transmission of tick-borne pathogens by decreasing exposure of susceptible hosts to ticks. The recently discovered tick antigens, 64P putative cement protein and subolesin involved in the regulation of tick feeding and reproduction, were also shown to reduce tick infestations. These antigens, together with the TROSPA receptor for Burrelia burgdorferi OspA were effective against tick-borne pathogens by reducing the infection levels in ticks and/or the transmission of the pathogen. Development of a vaccine targeted at both the tick vector and pathogen would contribute greatly to the control of tick infestations and the transmission of tick-borne diseases. These results have demonstrated that tick vaccines can be developed for control tick infestations and show promise for the prevention of the transmission of tick-borne pathogens.


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Copyright information

© Springer 2007

Authors and Affiliations

  • J. de la Fuente
    • 1
    • 2
    Email author
  • K. M. Kocan
    • 1
  • E. F. Blouin
    • 1
  1. 1.Department of Veterinary Pathobiology, Center for Veterinary Health SciencesOklahoma State UniversityStillwaterUSA
  2. 2.Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM)Ciudad RealSpain

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