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Veterinary Research Communications

, Volume 30, Issue 4, pp 403–413 | Cite as

Dietary Supplements of Vitamins E and C and β-Carotene Reduce Oxidative Stress in Cats with Renal Insufficiency

  • S. YuEmail author
  • I. Paetau-Robinson
Article

Abstract

Oxidative stress may contribute to the progression of chronic renal failure. In this study, cats with spontaneous renal insufficiency were fed a dry cat food supplemented with the antioxidants vitamins E and C, and β-carotene for 4 weeks. When compared with healthy cats, cats with renal insufficiency had a tendency to oxidative stress. The antioxidant supplements significantly reduced DNA damage in cats with renal insufficiency as evidenced by reduced serum 8-OHdG and comet assay parameters. Therefore, supplements of vitamins E and C and β-carotene as antioxidants may be beneficial to cats with renal disease.

Keywords

antioxidants cats DNA damage oxidative stress renal insufficiency 

Abbreviations

8-OHdG

8-hydroxy-2'-deoxyguanosine

HPLC

high-performance liquid chromatography

MDA

malondialdehyde

ORAC

oxygen radical absorption capacity

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  1. 1.Hill's Science and Technology CenterTopekaUSA

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