Dietary Supplements of Vitamins E and C and β-Carotene Reduce Oxidative Stress in Cats with Renal Insufficiency
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Oxidative stress may contribute to the progression of chronic renal failure. In this study, cats with spontaneous renal insufficiency were fed a dry cat food supplemented with the antioxidants vitamins E and C, and β-carotene for 4 weeks. When compared with healthy cats, cats with renal insufficiency had a tendency to oxidative stress. The antioxidant supplements significantly reduced DNA damage in cats with renal insufficiency as evidenced by reduced serum 8-OHdG and comet assay parameters. Therefore, supplements of vitamins E and C and β-carotene as antioxidants may be beneficial to cats with renal disease.
Keywordsantioxidants cats DNA damage oxidative stress renal insufficiency
high-performance liquid chromatography
oxygen radical absorption capacity
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- Allen, T.A., Polzin, D.J. and Adams, L.G., 2000. Renal disease. In: M.S. Hand, C.D. Thatcher, R.L. Remillard and P. Roudebush (eds), Small Animal Clinical Nutrition, 4th edn, (Mark Morris Institute, Topeka, KS), 563–604Google Scholar
- Collins, A., Dusinska, M., Franklin, M., Somorovska, M., Petrovska, H., Duthie, S., Fillion, L., Panayiotidis, M., Raslova, K. and Vaughan, N., 1997. Comet assay in human biomonitoring studies: reliability, validation, and applications. Environmental and Molecular Mutagenesis, 30, 139–146CrossRefPubMedGoogle Scholar
- Gunter, E.W., Lewis, B.G. and Koncikowski, S.M., 1996. Laboratory Procedures Used for the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994, (US Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, and National Center for Health Statistics, Hyattsville, MD), VII-F-1–VII-F-12Google Scholar
- Harper, E.J., 2000. Antioxidant compositions and method for companion animals. Patent Publication WO00/44375.Google Scholar
- Hidiroglou, M., Batra, T.R. and Zhao, X., 1997. Comparison of vitamin C bioavailability after multiple or single oral dosing of different formulations in sheep. Reproduction Nutrition Development, 37, 443–448Google Scholar
- Osawa, T., Yoshida, A., Kawakishi, S., Yamashita, K. and Ochi, H., 1995. Protective role of dietary antioxidants in oxidative stress. In: R.G. Cutler, L. Packer, J. Bertram and A. Mori (eds), Oxidative Stress and Aging (Birkhauser Verlag, Boston), 367–377Google Scholar