The epidemiology and role of surgery in the treatment of urethral clear cell carcinoma
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To perform a retrospective analysis of the epidemiology and role of surgery on survival in patients with urethral clear cell carcinoma (UCCC) using the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database.
UCCC cases diagnosed from January 1, 1973, to December 31, 2014, were extracted from SEER. Descriptive statistics were calculated for all variables. Univariate analysis to assess for differences in survival with respect to covariates was performed using the log-rank test. Multivariate analysis was performed with Cox proportional hazards regression models to determine the predictive performance of covariates with respect to overall survival (OS) and disease-specific survival (DSS), reported as hazard ratio (HR) with 95% CIs. Comparisons were considered statistically significant at P < 0.05.
Sixty-one cases were extracted for analysis. Mean age ± SD was 63.0 ± 13.9 years. Fifty (82%), 18 (29.5%), and 14 (23.0%) patients underwent surgery, radiation, and chemotherapy, respectively. On univariate analysis, the following covariates were associated with both OS and DSS: age, stage, and surgery (all P < 0.001). On multivariate analysis, surgery was a predictor for improved OS and DSS (HR, 0.178; 95% CI [0.068; 0.464]) and HR, 0.166; 95% CI [0.057; 0.484], respectively). Neither radiation nor chemotherapy was significantly associated with OS or DSS.
Surgery was associated with improved OS and DSS in patients with UCCC. While neither radiation nor chemotherapy was significantly associated with survival, additional studies are necessary to determine how these therapeutic interventions may impact prognosis.
KeywordsUrethra Clear cell SEER Epidemiology Survival
No funding was provided for this study.
Compliance with ethical standards
Conflict of interest
All authors declare that they have no conflicts of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
- 5.Eble JN et al (2004) Pathology and genetics of tumours of the urinary system and male genital organs. IARC Press, LyonGoogle Scholar
- 7.Oliva E, Young RH (1996) Clear cell adenocarcinoma of the urethra: a clinicopathologic analysis of 19 cases. Modern Pathol 9(5):513–520Google Scholar
- 10.Sheahan G, Vega AV (2013) Primary clear cell adenocarcinoma in a female urethral diverticulum: a case report and review. World J Nephrol Urol 2:29–32Google Scholar
- 12.National Cancer Institiue (2019) Overview of the SEER program 2019. Available at: http://seer.cancer.gov/about/overview.html. Accessed 22 Feb 2019