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International Urology and Nephrology

, Volume 51, Issue 12, pp 2227–2233 | Cite as

Treatment of asymptomatic hyperuricemia complicated by renal damage: a controversial issue

  • Chun Hu
  • Xiaoyan WuEmail author
Nephrology - Review
  • 144 Downloads

Abstract

The prevalence of asymptomatic HUA is increasing year after year. HUA is a risk factor for the occurrence and development of renal diseases. However, the role of urate-lowering therapy in asymptomatic HUA complicated by renal damage is still controversial. In some experiments, the treatment of asymptomatic HUA complicated by renal damage may delay the progression of kidney damage. In addition, there is increasing evidence, suggesting that elevated serum uric acid is an independent risk factor for kidney disease. However, in other studies, uric acid-lowering therapy did not improve renal function, and uric acid levels could not be used as an independent predictor for CKD development. Further experimental studies are needed to determine the starting threshold and target value of asymptomatic HUA complicated by renal damage. At the same time, confirmation of the benefits of urate-lowering therapy for kidneys requires studies with larger samples and high-quality RCTs.

Keywords

Asymptomatic HUA Urate-lowering therapy Renal damage 

Notes

Funding

This work was supported by fundamental research funds for central universities (2042018kf0142).

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of NephrologyZhongnan Hospital of Wuhan UniversityWuhanChina

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