International Urology and Nephrology

, Volume 51, Issue 4, pp 571–577 | Cite as

Urinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children

  • Tülay Becerir
  • Selcuk YükselEmail author
  • Havva Evrengül
  • Ahmet Ergin
  • Yaşar Enli
Urology - Original Paper



Acute pyelonephritis is associated with considerable morbidity and potential for renal scarring. Pentraxin3 (PTX3) is a recently discovered mediator of inflammation. The objective of this study was to investigate the changes in serum and urine PTX3 levels in children who had a history of pyelonephritis and were diagnosed with renal parenchymal scar (RPS) and/or vesicoureteral reflux (VUR).


The study included 88 children (31 males, 57 females) aged between 3 months and 18 years. The children included in the study were divided into four groups: VUR with RPS (Group 1), RPS without VUR (Group 2), VUR without RPS (Group 3), and healthy children without a history of hydronephrosis or UTI history (Group 4). After the initial evaluation, the participants were further divided into two more groups and re-evaluated: Children with RPS (Group 1 + 2), children without RPS (Group 3 + 4), children with VUR (Group 1 + 3), and children without VUR (Group 2 + 4).


We found that urine pentraxin 3 (uPTX3) and uPTX3/Creatinine levels were significantly higher in the groups with renal scar with or without VUR than the ones without RPS [mean uPTX3, 3.5 pg/ml (min–max 0.0022–12.3668) vs. 2.2 pg/ml (min–max 0.0022–18.5868) and uPTX3/creatinine, 10.5 pg/mg (min–max 0.0035–51.1) vs. 5.8 pg/mg (min–max 0.0004–78.7), p < 0.01]. uPTX3 levels were not different among the groups with and without VUR. In addition, serum PTX3 levels were not different among the groups.


We showed that urinary PTX3 increased only in patients with scarred kidneys. These results might be helpful to predict RPS due to past pyelonephritis.


Children Pentraxin 3 Renal scar Vesicoureteral reflux 


Author contributions

TB conceptualized and designed the study, drafted the initial manuscript. TB, HE, and YE carried out the initial analyses, reviewed, and revised the manuscript. AE supervised the statistics. SY made critical revision of the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.


This research has been supported by Pamukkale University Research Fund (Number 2015HZL007).

Compliance with ethical standards

Conflict of interest

No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

Ethical approval

The study was approved by the Pamukkale University Ethics Committee (IRB number 60116787-020/549639).


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of Pediatric NephrologyNamık Kemal University School of MedicineTekirdağTurkey
  2. 2.Department of Pediatric Rheumatology and NephrologyPamukkale University School of MedicineKınıklı Yerleşkesi/DenizliTurkey
  3. 3.Department of Pediatric NephrologyPamukkale University School of MedicineKınıklı Yerleşkesi/DenizliTurkey
  4. 4.Department of Social PediatricsPamukkale University School of MedicineKınıklı Yerleşkesi/DenizliTurkey
  5. 5.Department of BiochemistryPamukkale University School of MedicineKınıklı Yerleşkesi/DenizliTurkey

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