Evaluating the associations between urinary excretion of magnesium and that of other components in calcium stone-forming patients
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Magnesium plays numerous vital roles in human’s body. It is known as a protective factor in stone formation by binding to oxalate in the intestinal and urinary system, and decreasing its absorption and crystallization, respectively. Due to controversies about the association between the 24-h urine magnesium and other urine metabolites in different studies, this study was designed to find a clear answer to this question.
In this retrospective cross-sectional study, data from 24-h urinalysis of the calcium stone-forming (CSF) patients were assessed. The correlation between 24-h urine (24-U) magnesium to creatinine ratio (Mg/Cr) with other 24-U metabolites to creatinine ratio was assessed, using Spearman correlation test. The association between 24-U magnesium and 24-U oxalate was also studied in a multivariate logistic regression model.
Among 965 patients, the level of Mg/Cr showed a direct association with all other 24-U metabolite to Cr ratio (p-value < 0.001 for all analyses). The result of multivariate regression analysis showed that the higher quartile of 24-U oxalate (> 47 mg/24 h) increased the odds of 24-U magnesium more than 75 mg/24 h (data median) (OR 1.89, 95% CI 1.14–3.13) comparing with the lower quartile of 24-U oxalate (≤ 26 mg/24 h).
In a routine dietary habit, since rich sources of magnesium contain a high amount of oxalate at the same time, it is not surprising that magnesium level in 24-h urinalysis showed a direct association with 24-h urine oxalate.
KeywordsAssociation Calcium stones Magnesium Oxalate Urine metabolites
We thank our colleagues from Shahid Labbafinejad Medical Center for their kind cooperation in our study.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the Urology Nephrology Research Center institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
For this type of study formal consent is not required.
- 3.Shils ME, Shike M (2006) Modern nutrition in health and disease. Lippincott Williams & Wilkins, BaltimoreGoogle Scholar
- 7.Preminger G, Baker S, Peterson R, Poindexter J, Pak C (1989) Hypomagnesiuric hypocitraturia: an apparent new entity for calcium nephrolithiasis. J Lithotr Stone Dis 1:22–25Google Scholar
- 10.Türk C, Neisius A, Petrik A, Seitz C, Skolarikos A, Thomas K (2017) EAU guidelines on urolithiasis european association of urology. http://uroweb.org/guideline/urolithiasis/
- 15.Türk C, Knoll T, Petrik A, Sarica K, Straub M, Seitz C (2012) EAU guiedline in urolithiasis. European Association of Urology. https://uroweb.org/wp-content/uploads/20_Urolithiasis_LR-March-13-2012.pdf
- 16.Favus MJ, Goltzman G (2008) Regulation of calcium and magnesium. In: Rosen CJ, Bouillon R, Compston JE, Rosen V (eds) Primer on the metabolic bone diseases and disorders of mineral metabolism. Wiley, New York, pp 104–108Google Scholar