International Urology and Nephrology

, Volume 51, Issue 1, pp 163–174 | Cite as

Effects of sleep disorders and sedative–hypnotic medications on health-related quality of life in dialysis patients

  • Chenfei Zheng
  • Jinglin Xu
  • Chaosheng Chen
  • Fan Lin
  • Rongrong Shao
  • Ze Lin
  • Yi LiuEmail author
  • Ying ZhouEmail author
Nephrology - Original Paper



Sleep disorders are very common among dialysis patients, leading patients to frequently take sedative–hypnotic medications; however, the effects of sleep disorders and the use of such drugs on health-related quality of life (HRQOL) have rarely been investigated.


The Pittsburgh Sleep Quality Index and Short Form-12 were used to assess sleep quality and patient health situations, respectively. Logistic regression was employed to identify factors associated with deterioration of the mental component summary (MCS) score and the physical component summary (PCS) score.


A total of 461 patients undergoing dialysis were recruited. The prevalence of sleep disorders was 67.0%. Among the study population, 30.4% of patients took sedative–hypnotic medications to improve their sleep quality. Both the PCS (81.25 vs. 71.88, p < 0.001) and MCS scores (78.63 vs. 74.63, p < 0.001), which indicate HRQOL, were decreased among patients with sleep disorders compared with good sleepers. However, neither the PCS nor MCS scores showed any significant difference between patients with sleep disorders who used sedative–hypnotic medications and those who did not.


Sleep disorders were closely associated with deterioration of both mental HRQOL and physical HRQOL. Sedative–hypnotic medication use did not affect HRQOL among patients with sleep disorders undergoing dialysis.


Dialysis MCS PCS Sedative–hypnotic medications Sleep disorders Quality of life 



This work was supported by grants from the Wenzhou Committee of Science and Technology of China (ZS2017008 and Y20170055), the Zhejiang Province Natural Science Foundation (LY14H050006, Q19H050010 and LY16H150007), the Guangdong Medical Science and Technology Research Fund Project of China (A2018042), and the Guangzhou Science and Technology Project of China (20170420167).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of NephrologyThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina
  2. 2.Department of NephrologyTaizhou First Person’s HospitalTaizhouChina

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