Excitatory and inhibitory effects of stimulation of sacral dorsal root ganglion on bladder reflex in cats
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To explore the effects of electrical stimulation of the sacral dorsal root ganglion (DRG) on bladder reflexes in α-chloralose-anesthetized cats.
Bladder activity was recorded under isovolumetric conditions. A pair of hook electrodes was placed in the right S1 and S2 DRGs of 12 adult male cats, which were stimulated over a range of frequencies (0.25–30 Hz) and at threshold intensity.
Stimulation of S1 and S2 DRGs inhibited or evoked bladder contractions under isovolumetric conditions depending on the frequency of stimulation in nine cats. Stimulation at low frequencies (3–7 Hz on S1 or S2 DRG) significantly inhibited isovolumetric rhythmic bladder contractions, while excitatory effects were observed at two frequency ranges, including lower frequencies (0.25–1.5 Hz on S1 DRG and 0.25–1.25 Hz on S2 DRG) and middle frequencies (15–30 Hz on S1 and S2 DRGs).
These results suggest that the sacral DRG might be a potential valuable target for electrical stimulation in the treatment of bladder dysfunction.
KeywordsSacral dorsal root ganglion Electrical stimulation Frequency Bladder reflex Cats
This study was funded by Research Projects of China Rehabilitation Research Center (2017ZX-31 and 2016CZ-1) and National Natural Science Foundation of China (Grand No. 81570688).
Compliance with ethical standards
Conflict of interest
No potential conflict of interest relevant to this article was reported.
All animal experiments were performed ethically in accordance with Capital Medical University guidelines for animal care and use.
Research involving human and animal participants
Human subjects were not used in this study.