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Excitatory and inhibitory effects of stimulation of sacral dorsal root ganglion on bladder reflex in cats

  • Zhaoxia Wang
  • Han Deng
  • Limin Liao
  • Tianji Lu
  • Xing Li
Urology - Original Paper
  • 8 Downloads

Abstract

Purpose

To explore the effects of electrical stimulation of the sacral dorsal root ganglion (DRG) on bladder reflexes in α-chloralose-anesthetized cats.

Methods

Bladder activity was recorded under isovolumetric conditions. A pair of hook electrodes was placed in the right S1 and S2 DRGs of 12 adult male cats, which were stimulated over a range of frequencies (0.25–30 Hz) and at threshold intensity.

Results

Stimulation of S1 and S2 DRGs inhibited or evoked bladder contractions under isovolumetric conditions depending on the frequency of stimulation in nine cats. Stimulation at low frequencies (3–7 Hz on S1 or S2 DRG) significantly inhibited isovolumetric rhythmic bladder contractions, while excitatory effects were observed at two frequency ranges, including lower frequencies (0.25–1.5 Hz on S1 DRG and 0.25–1.25 Hz on S2 DRG) and middle frequencies (15–30 Hz on S1 and S2 DRGs).

Conclusions

These results suggest that the sacral DRG might be a potential valuable target for electrical stimulation in the treatment of bladder dysfunction.

Keywords

Sacral dorsal root ganglion Electrical stimulation Frequency Bladder reflex Cats 

Notes

Funding

This study was funded by Research Projects of China Rehabilitation Research Center (2017ZX-31 and 2016CZ-1) and National Natural Science Foundation of China (Grand No. 81570688).

Compliance with ethical standards

Conflict of interest

No potential conflict of interest relevant to this article was reported.

Ethical approval

All animal experiments were performed ethically in accordance with Capital Medical University guidelines for animal care and use.

Research involving human and animal participants

Human subjects were not used in this study.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Urology, China Rehabilitation Research CentreRehabilitation School of Capital Medical UniversityBeijingChina
  2. 2.Beijing Key Laboratory of Neural Injury and RehabilitationBeijingChina
  3. 3.Center of Neural Injury and RepairBeijing Institute for Brain DisordersBeijingChina

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